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dc.contributor.author
Marinelli, Raul Alberto
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dc.contributor.author
Vore, Mary
dc.contributor.author
Javitt, Norman B.
dc.date.available
2020-12-16T19:34:52Z
dc.date.issued
2019-12
dc.identifier.citation
Marinelli, Raul Alberto; Vore, Mary; Javitt, Norman B.; Hepatic bile formation: Canalicular osmolarity and paracellular and transcellular water flow; American Society for Pharmacology and Experimental Therapeutics; Journal of Pharmacology and Experimental Therapeutics; 371; 3; 12-2019; 713-717
dc.identifier.issn
0022-3565
dc.identifier.uri
http://hdl.handle.net/11336/120606
dc.description.abstract
The purpose of this minireview is to show that a new paradigm is developing regarding hepatic bile flow. The focus thus far has been on carrier-mediated transport of bile acids and other solutes, such as glutathione, which create an osmotic gradient for the transcellular and paracellular flow of water into canaliculi. In addition to the physicochemical properties of bile acids, which govern the osmotic gradient, data now exist showing that the tight junctions governing paracellular water flow and Aquaporin-8 water channels governing transcellular water flow are regulated independently. Thus, the rate of water flow into the canaliculus in response to bile acid transport is variable and determines canalicular bile acid concentration, which affects the production and solubilization of cholesterol-lecithin vesicles. These new considerations modify thinking regarding the occurrence of cholestasis and its progression and reorient the design of experimental studies that can distinguish the different determinants of bile flow. SIGNIFICANCE STATEMENT The paradigm that water flow into the canaliculus is determined only by the rate of carrier-mediated transport has been challenged recently by the changes that occur in hepatic bile composition in the Claudin-2 knockout mouse and with the cholestatic effect of estradiol 17b-D-glucuronide. Thus, a respective reduction in paracellular or transcellular canalicular water flow, probably via Aquaporin 8, has no significant effect on bile acid excretion.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Pharmacology and Experimental Therapeutics
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Canalicular bile
dc.subject
Water flow
dc.subject
Aquaporin-8
dc.subject
Estradiol 17b-D-glucuronide
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Hepatic bile formation: Canalicular osmolarity and paracellular and transcellular water flow
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T21:45:25Z
dc.journal.volume
371
dc.journal.number
3
dc.journal.pagination
713-717
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Baltimore
dc.description.fil
Fil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
dc.description.fil
Fil: Vore, Mary. University of Kentucky; Estados Unidos
dc.description.fil
Fil: Javitt, Norman B.. University of New York. School of Medicine; Estados Unidos
dc.journal.title
Journal of Pharmacology and Experimental Therapeutics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1124/jpet.119.261115
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://jpet.aspetjournals.org/content/371/3/713
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