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Artículo

IFN-α-2b treatment protects against diet-induced obesity and alleviates non-alcoholic fatty liver disease in mice

Quiroga, Ariel DarioIcon ; Comanzo, Carla GabrielaIcon ; Heit Barbini, Francisco J.; Lucci, AlvaroIcon ; Vera, Marina CeciliaIcon ; Lorenzetti, FlorenciaIcon ; Ferretti, AnabelaIcon ; Ceballos Mancini, María PaulaIcon ; Alvarez, María de Los ÁngelesIcon ; Carrillo, María C.
Fecha de publicación: 09/2019
Editorial: Academic Press Inc Elsevier Science
Revista: Toxicology and Applied Pharmacology
ISSN: 0041-008X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

IFN-α is used for inflammatory purposes, and obesity and NAFLD are strongly correlated with inflammatory processes. We wondered whether IFN-α-2b can attenuate obesity development and its associated NAFLD in mice fed high fat diet (HFD) for 10 weeks. IFN-α-2b had a robust effect on body weight loss associated with NAFLD amelioration by decreasing hepatic inflammation. IFN-α-2b-treated mice showed increased plasma cholesterol levels together with decreased hepatic cholesterol, both on chow and HF diets. Interestingly, mice on IFN-α-2b treatment secreted smaller VLDL particles highly enriched in cholesterol. Mechanistically, we found that IFN-α-2b antiobesity effects were related to increased fatty acid oxidation; and its effects on cholesterol metabolism were due to both a decrease in the master cholesterogenic transcription factor SREBP-2 and in the rate limiting enzyme in cholesterol synthesis, HMGCR. To our knowledge, this is the first report showing the effects of IFN-α-2b on the prevention of the development of HFD-induced body weight gain and dyslipidemia through a mechanism that involves fatty acid oxidation and cholesterol decrease. These studies comprise necessary steps for understanding the amelioration of obesity and NAFLD. Results shed some light into the mechanism of action of natural cytokines, and their effects on ameliorating obesity and its related diseases.
Palabras clave: HYPERTRIGLYCERIDEMIA , LIPID METABOLISM , LIPIDS , LIVER , METABOLIC SYNDROME
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/120602
URL: https://www.sciencedirect.com/science/article/pii/S0041008X19302583
DOI: https://doi.org/10.1016/j.taap.2019.114650
Colecciones
Articulos(IFISE)
Articulos de INST.DE FISIOLOGIA EXPERIMENTAL (I)
Citación
Quiroga, Ariel Dario; Comanzo, Carla Gabriela; Heit Barbini, Francisco J.; Lucci, Alvaro; Vera, Marina Cecilia; et al.; IFN-α-2b treatment protects against diet-induced obesity and alleviates non-alcoholic fatty liver disease in mice; Academic Press Inc Elsevier Science; Toxicology and Applied Pharmacology; 379; 9-2019; 1-13; 114650
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