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dc.contributor.author
Perez Lloret, Santiago
dc.contributor.author
Bernath, V.
dc.contributor.author
Barrantes, Francisco Jose
dc.contributor.other
Gargiulo, Pascual Angel
dc.contributor.other
Mesones Arroyo, Humberto Luis
dc.date.available
2020-12-16T14:25:49Z
dc.date.issued
2019
dc.identifier.citation
Perez Lloret, Santiago; Bernath, V.; Barrantes, Francisco Jose; Genetic factors influencing the development and treatment of cognitive impairment and psychosis in Parkinson´s Disease; Springer; 3; 2019; 359-370
dc.identifier.isbn
978-3-319-95359-5
dc.identifier.uri
http://hdl.handle.net/11336/120567
dc.description.abstract
Parkinson’s disease (PD) is a neurodegenerative disease in which both genetic and environmental factors play significant roles. In addition to increasing the risk of developing PD, gene mutations might also influence the phenotypical characteristics of the disease, including the development of cognitive impairment and psychosis. For instance, mutations of the GBA gene, which encodes the enzyme γ-glucocerebrosidase, have been related to cognitive impairment or dementia and visual hallucinations. Interest in the APOE gene, which encodes the apolipoprotein E, stems from the finding of increased Alzheimer’s disease risk in carriers of APOE ε4 alleles. In a cohort of 390 PD patients, APOE ε4 allele carriers showed significantly increased cognitive decline during the 2-year follow-up period...
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Parkinson´s disease
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Psychosis
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Cognitive impairment
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Genetics of psychiatric diseases
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Psiquiatría
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Genetic factors influencing the development and treatment of cognitive impairment and psychosis in Parkinson´s Disease
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-11-25T20:15:23Z
dc.journal.volume
3
dc.journal.pagination
359-370
dc.journal.pais
Suiza
dc.description.fil
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Bernath, V.. No especifíca;
dc.description.fil
Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/chapter/10.1007/978-3-319-95360-1_29
dc.conicet.paginas
465
dc.source.titulo
Psychiatry and Neuroscience Update. From Translational Research to a Humanistic Approach
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