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dc.contributor.author
Egorov, Alexei V.
dc.contributor.author
Schumacher, Dagmar
dc.contributor.author
Medert, Rebekka
dc.contributor.author
Birnbaumer, Lutz
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dc.contributor.author
Freichel, Marc
dc.contributor.author
Draguhn, Andreas
dc.date.available
2020-12-16T14:01:17Z
dc.date.issued
2019-11
dc.identifier.citation
Egorov, Alexei V.; Schumacher, Dagmar; Medert, Rebekka; Birnbaumer, Lutz; Freichel, Marc; et al.; TRPC channels are not required for graded persistent activity in entorhinal cortex neurons; Veterinary and Human Toxicology; Hippocampus; 29; 11; 11-2019; 1038-1048
dc.identifier.issn
1050-9631
dc.identifier.uri
http://hdl.handle.net/11336/120563
dc.description.abstract
Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained (“persistent”) neuronal firing which may be generated by cell-autonomous biophysical properties of neurons or/and neural circuit dynamics. A number of studies from brain slices reports intrinsically generated persistent firing in cortical excitatory neurons following suprathreshold depolarization by intracellular current injection. In layer V (LV) neurons of the medial entorhinal cortex (mEC) persistent firing depends on the activation of cholinergic muscarinic receptors and is mediated by a calcium-activated nonselective cation current (ICAN). The molecular identity of this conductance remains, however, unknown. Recently, it has been suggested that the underlying ion channels belong to the canonical transient receptor potential (TRPC) channel family and include heterotetramers of TRPC1/5, TRPC1/4, and/or TRPC1/4/5 channels. While this suggestion was based on pharmacological experiments and on effects of TRP-interacting peptides, an unambiguous proof based on TRPC channel-depleted animals is pending. Here, we used two different lines of TRPC channel knockout mice, either lacking TRPC1-, TRPC4-, and TRPC5-containing channels or lacking all seven members of the TRPC family. We report unchanged persistent activity in mEC LV neurons in these animals, ruling out that muscarinic-dependent persistent activity depends on TRPC channels.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Veterinary and Human Toxicology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
HEPTA-TRPC KO MICE
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MUSCARINIC
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PERSISTENT FIRING
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TRPC1/4/5 KO MICE
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
TRPC channels are not required for graded persistent activity in entorhinal cortex neurons
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-25T16:38:09Z
dc.journal.volume
29
dc.journal.number
11
dc.journal.pagination
1038-1048
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Egorov, Alexei V.. Universität Heidelberg; Alemania
dc.description.fil
Fil: Schumacher, Dagmar. Universität Heidelberg; Alemania
dc.description.fil
Fil: Medert, Rebekka. Universität Heidelberg; Alemania
dc.description.fil
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Freichel, Marc. Universität Heidelberg; Alemania
dc.description.fil
Fil: Draguhn, Andreas. Universität Heidelberg; Alemania
dc.journal.title
Hippocampus
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hipo.23094
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/hipo.23094
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791731/
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