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dc.contributor.author
Tibayrenc, Michel
dc.contributor.author
Telleria, Jenny
dc.contributor.author
Diosque, Patricio
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dc.contributor.author
Dib, Juan Carlos
dc.contributor.author
Barnabé, Christian
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dc.contributor.other
Tibayrenc, Michel
dc.date.available
2020-12-15T20:46:49Z
dc.date.issued
2011
dc.identifier.citation
Tibayrenc, Michel ; Telleria, Jenny ; Diosque, Patricio; Dib, Juan Carlos; Barnabé, Christian; Integrated Genetic Epidemiology of Chagas Disease; Elsevier; 2011; 637-650
dc.identifier.isbn
978-0-12-384890-1
dc.identifier.uri
http://hdl.handle.net/11336/120531
dc.description.abstract
This chapter states that the term “integrated genetic epidemiology” has been coined to designate the approach consisting in simultaneously analyzing the impact of the host's, the pathogen's, and the vector's genetic diversity on the transmission and severity of infectious diseases as well as the coevolution processes between the three. It briefly summarizes what is presently known about: (i) human genetic susceptibility to Chagas disease, (ii) the vectors' species and population diversity, and (iii) the parasite's genetics and evolution. Chagas disease is a very serious illness. After infection by the parasite, patients develop an acute phase, which actually corresponds to parasitic septicemia. The most worrisome symptom is Chagasic cardiopathy, which leads to a severe cardiac insufficiency. The causative agent of Chagas disease is a parasitic protozoan of the family Kinetoplastidae. Trypanosoma cruzi is transmitted by “true” bugs. Human genetic susceptibility to Chagas disease is less well known than for other transmissible diseases such as Hepatitis C, TB, malaria, AIDS, leprosy, schistosomiasis and visceral leishmaniosis. Chagas disease strikes populations that are ethnically very diverse. Latin Americans have European, African, Amerindian, and mixed ancestries. It has now been determined that the HLA supergene complex of several genes having a related role plays an important role in the transmission, severity, and clinical diversity of Chagas disease. Chagas disease exhibits a specific epidemiological feature, namely, that the parasite can be transmitted by an impressive range of different vectors. The interpretation of isoenzyme diversity in terms of population genetics and evolutionary biology has made it possible to clarify the evolutionary status of the zymodemes. When natural cycles are considered, possible protocols could be to compare T. cruzi genotypes isolated from (i) cardiac versus digestive versus ASY patients, (ii) different mammal species, and (iii) different triatomine bug species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Genetics
dc.subject
Evolution
dc.subject
Infectious Diseases
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Integrated Genetic Epidemiology of Chagas Disease
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-05-19T19:44:23Z
dc.journal.pagination
637-650
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Tibayrenc, Michel. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Telleria, Jenny. Centre National de la Recherche Scientifique; Francia
dc.description.fil
Fil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
dc.description.fil
Fil: Dib, Juan Carlos. Universidad de Antioquia; Colombia
dc.description.fil
Fil: Barnabé, Christian. Centre National de la Recherche Scientifique; Francia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/B978-0-12-384890-1.00023-6
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B9780123848901000236
dc.conicet.paginas
749
dc.source.titulo
Genetics and Evolution of Infectious Diseases
dc.conicet.nroedicion
1ra
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