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dc.contributor.author
Vigo, Daniel Eduardo
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dc.contributor.author
Cardinali, Daniel Pedro
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dc.contributor.other
Gargiulo, Pascual Angel
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dc.contributor.other
Mesones Arroyo, Humberto Luis
dc.date.available
2020-12-15T14:36:16Z
dc.date.issued
2019
dc.identifier.citation
Vigo, Daniel Eduardo; Cardinali, Daniel Pedro; Melatonin and Benzodiazepine/Z-Drug Abuse; Springer; III; 2019; 427-451
dc.identifier.isbn
978-3-319-95359-5
dc.identifier.uri
http://hdl.handle.net/11336/120452
dc.description.abstract
A temporal relationship between the nocturnal rise in melatonin secretion and the increase in sleep propensity at the beginning of the night, coupled with the sleep-promoting effects of exogenous melatonin, supports the view that melatonin is involved in the regulation of sleep. Both meta-analyses and consensus agreements give credibility to the therapeutic use of melatonin in sleep disorders. Administration of melatonin will cue the circadian phase of sleep/wake cycles in a variety of disorders including jet lag problems, shift work maladaptation, advanced and delayed sleep phase disorders, major affective disorder, seasonal affective disorder, and disrupted rhythms in attention deficit hyperactivity disorder, autism, and schizophrenia. This action is attributed to MT1 and MT2 melatonin receptors present in the hypothalamic suprachiasmatic nucleus (SCN) and in other brain areas. Almost every single neuron in the SCN contains GABA, and many results in animals point out to a melatonin interaction with GABA-containing neurons. In addition, central-type benzodiazepine (BZD) antagonism that obliterates GABAA receptor function blunted melatonin behavioral effects including sleep. The sleep-promoting activity of melatonin is relevant because the BZD and type Z-drugs usually prescribed as sleep promoters have many adverse effects, such as next-day hangover, dependence, and impairment of memory. This chapter discusses available data on the efficacy of melatonin to curtail chronic BZD/Z-drug use in insomnia patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INSOMNIA
dc.subject
MELATIONIN
dc.subject
BENZODIAZEPINS
dc.subject
Z-DRUGS
dc.subject
DRUG ABUSE
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Melatonin and Benzodiazepine/Z-Drug Abuse
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-11-25T20:15:11Z
dc.journal.volume
III
dc.journal.pagination
427-451
dc.journal.pais
Suiza
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dc.description.fil
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phrs.2015.08.016
dc.conicet.paginas
465
dc.source.titulo
Psychiatry and Neuroscience Update: From Translational Research to a Humanistic Approach
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