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Artículo

Chronic treatment with C-type natriuretic peptide impacts differently in the aorta of normotensive and hypertensive rats

Caniffi, Carolina CeciliaIcon ; Cerniello, Flavia MicaelaIcon ; Bouchet, Gonzalo; Sueiro, María Lorena; Tomat, Analia LorenaIcon ; Gonzalez Maglio, Daniel HoracioIcon ; Toblli, Jorge EduardoIcon ; Arranz, Cristina TeresaIcon
Fecha de publicación: 08/2019
Editorial: Springer
Revista: Pflugers Archiv-European Journal of Physiology
ISSN: 0031-6768
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

The aim of this study was to determine whether exogenous administration of C-type natriuretic peptide (CNP) induces functional and morphological vascular changes in spontaneously hypertensive rats (SHR) compared with normotensive rats. Male 12-week-old normotensive Wistar and SHR were administered with saline (NaCl 0.9%) or CNP (0.75 μg/h/100 g) for 14 days (subcutaneous micro-osmotic pumps). Systolic blood pressure (SBP) was measured in awake animals and renal parameters were evaluated. After decapitation, the aorta was removed, and vascular morphology, profibrotic markers, and vascular reactivity were measured. In addition, nitric oxide (NO) system and oxidative stress were evaluated. After 14-days of treatment, CNP effectively reduced SBP in SHR without changes in renal function. CNP attenuated vascular remodeling in hypertensive rats, diminishing both profibrotic and pro-inflammatory cytokines. Also, CNP activated the vascular NO system and exerted an antioxidant effect in aortic tissue of both groups, diminishing superoxide production and thiobarbituric acid-reactive substances, and increasing glutathione content. These results show that chronic treatment with CNP attenuates the vascular damage development in a model of essential hypertension, inducing changes in fibrotic, inflammatory, oxidative, and NO pathways that could contribute to beneficial long-term effects on vascular morphology, extracellular matrix composition, and function. The knowledge of these effects of CNP could lead to improved therapeutic strategies to not only control BP but also reduce vascular damage, primarily responsible for the risk of cardiovascular events.
Palabras clave: BLOOD PRESSURE , FIBROSIS , NATRIURETIC PEPTIDES , NITRIC OXIDE , OXIDATIVE STRESS , VASCULAR REMODELING
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/120349
URL: https://link.springer.com/article/10.1007%2Fs00424-019-02287-y
DOI: http://dx.doi.org/10.1007/s00424-019-02287-y
Colecciones
Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Caniffi, Carolina Cecilia; Cerniello, Flavia Micaela; Bouchet, Gonzalo; Sueiro, María Lorena; Tomat, Analia Lorena; et al.; Chronic treatment with C-type natriuretic peptide impacts differently in the aorta of normotensive and hypertensive rats; Springer; Pflugers Archiv-European Journal of Physiology; 471; 8; 8-2019; 1103-1115
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