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dc.contributor.author
Laiglecia, Juan Ignacio
dc.contributor.author
Estrada, Vanina Gisela
dc.contributor.author
Vidal Vidal, Rebeca
dc.contributor.author
Florencio, Francisco J.
dc.contributor.author
Guerrero, Miguel G.
dc.contributor.author
Diaz, Maria Soledad
dc.date.available
2017-01-26T19:51:04Z
dc.date.issued
2013-05
dc.identifier.citation
Laiglecia, Juan Ignacio; Estrada, Vanina Gisela; Vidal Vidal, Rebeca; Florencio, Francisco J.; Guerrero, Miguel G.; et al.; Dynamic Flux Balance Analysis of a Genetic Engineered Cyanobacterium for Ethanol Production: Parameter Estimation; Associazione Italiana Di Ingegneria Chimica; Chemical Engineering Transactions; 32; 5-2013; 955-960
dc.identifier.issn
1974-9791
dc.identifier.uri
http://hdl.handle.net/11336/12013
dc.description.abstract
In this work, we present parameter estimation problem for Dynamic Flux Balance Analysis to study the production of ethanol by a mutant strain of the cyanobacterium Synechocystis sp. PCC 6803, as well as experimental data. This modified strain harbors the genes pdc and adhII from Zymomonas mobilis. The model includes two major components: (1) a dynamic model with mass balances for biomass, ethanol, nitrate, phosphate, internal nitrogen and phosphorus, and (2) a steady state genome-scale metabolic LP model. The biomass equation includes limiting functions for temperature and kinetics of growth inhibition by ethanol toxicity. Limitation of light by biomass accumulation is also taken into account. We formulate a dynamic parameter estimation problem with a weighted least-squares objective function, subject to dynamic mass balance equations at the bioreactor level and the intracellular LP model. The problem is solved in GAMS through a simultaneous optimization approach. Data set for parameter estimation were obtained in experiments performed over 73 h in batch liquid cultures. Numerical results provide useful insights on ethanol production by the genetic modified strain within the context of genomic-scale cyanobacterial metabolism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Associazione Italiana Di Ingegneria Chimica
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Parameter Estimation
dc.subject
Dynamic Flux Balance Analysis
dc.subject
Ethanol Production
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Bilevel Programming
dc.subject.classification
Ingeniería de Procesos Químicos
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Ingeniería Química
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Dynamic Flux Balance Analysis of a Genetic Engineered Cyanobacterium for Ethanol Production: Parameter Estimation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-24T18:30:53Z
dc.journal.volume
32
dc.journal.pagination
955-960
dc.journal.pais
Italia
dc.journal.ciudad
Milán
dc.description.fil
Fil: Laiglecia, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Estrada, Vanina Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Vidal Vidal, Rebeca. Universidad de Sevilla. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Florencio, Francisco J.. Universidad de Sevilla. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Guerrero, Miguel G.. Universidad de Sevilla. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil
Fil: Diaz, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
dc.journal.title
Chemical Engineering Transactions
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.aidic.it/cet/13/32/160.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3303/CET1332160
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