Artículo
Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis
Abruzzese, Giselle Adriana
; Heber, María Florencia
; Campo Verde Arbocco, Fiorella
; Ferreira, Silvana Rocio
; Motta, Alicia Beatriz
Fecha de publicación:
02/2019
Editorial:
Cambridge University Press
Revista:
Journal of Developmental Origins of Health and Disease
ISSN:
2040-1744
e-ISSN:
2040-1752
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Fetal programming by androgen excess is hypothesized as one of the main factors contributing to the development of polycystic ovary syndrome (PCOS). PCOS is more than a reproductive disorder, as women with PCOS also show metabolic and other endocrine alterations. Since both ovarian and reproductive functions depend on energy balance, the alterations in metabolism may be related to reproductive alterations. The present study aimed to evaluate the effect of androgen excess during prenatal life on ovarian fuel sensors and its consequences on steroidogenesis. To this end, pregnant rats were hyperandrogenized with testosterone and the following parameters were evaluated in their female offspring: follicular development, PPARG levels, adipokines (including leptin, adiponectin, and chemerin as ovarian fuel sensors), serum gonadotropins (LH and FSH), the mRNA of their ovarian receptors, and the expression of steroidogenic mediators. At 60 days of age, the prenatally hyperandrogenized (PH) female offspring displayed both an irregular ovulatory phenotype and an anovulatory phenotype with altered follicular development and the presence of cysts. Both PH groups showed altered levels of both proteins and mRNA of PPARG and a different expression pattern of the adipokines studied. Although serum gonadotropins were not impaired, there were alterations in the mRNA levels of their ovarian receptors. The steroidogenic mediators Star, Cyp11a1, Cyp17a1, and Cyp19a1 were altered differently in each of the PH groups. We concluded that androgen excess during prenatal life leads to developmental programming effects that affect ovarian fuel sensors and steroidogenesis in a phenotype-specific way.
Palabras clave:
ADIPOKINES
,
OVARY
,
PCOS
,
PPARG
,
PRENATAL HYPERANDROGENISM
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Abruzzese, Giselle Adriana; Heber, María Florencia; Campo Verde Arbocco, Fiorella; Ferreira, Silvana Rocio; Motta, Alicia Beatriz; Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis; Cambridge University Press; Journal of Developmental Origins of Health and Disease; 10; 6; 2-2019; 645-658
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