Artículo
Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
Beltrame, Jimena Soledad
; Cañumil, Vanesa Alejandra
; Sordelli, Micaela Soledad
; Ribeiro, Maria Laura




Fecha de publicación:
08/2019
Editorial:
BioScientifica
Revista:
Reproduction
ISSN:
1470-1626
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female reproductive functions. This bioactive lipid has been also implicated in vascular functions during physiological and pathological conditions. In this regard, the establishment of a successful pregnancy requires proper coordination of vascular processes and remodeling of maternal blood vessels during early gestation. During this process, first trimester cytotrophoblast changes from an invasive to an endovascular phenotype and transforms uterine spiral arteries which are the nutrient supply for placenta and fetus. Here we present an overview of LPA participation in vascular remodeling and highlight the importance of LPA-LPA3 signaling during early gestation at the maternal-fetal interface.
Palabras clave:
LYSOPHOSPHATIDIC ACID
,
VASCULAR REMODELING
,
IMPLANTATION
,
LPA3
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Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Beltrame, Jimena Soledad; Cañumil, Vanesa Alejandra; Sordelli, Micaela Soledad; Ribeiro, Maria Laura; Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface; BioScientifica; Reproduction; 159; 2; 8-2019; 1-13
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