Show simple item record Barrionuevo, Pablo Alejandro Nicandro, Nathaniel McAnany, J. Jason Zele, Andrew J. Gamlin, Paul Cao, Dingcai 2017-01-26T19:38:08Z 2014-02
dc.identifier.citation Barrionuevo, Pablo Alejandro; Nicandro, Nathaniel; McAnany, J. Jason; Zele, Andrew J.; Gamlin, Paul; et al.; Assessing Rod, Cone, and Melanopsin Contributions to Human Pupil Flicker Responses; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 55; 2; 2-2014; 719-727
dc.identifier.issn 0146-0404
dc.description.abstract Purpose: To determine the relative contributions of rods, cones and melanopsin to pupil responses in humans using temporal sinusoidal stimulation for light levels spanning the low mesopic to photopic range. Methods: A four-primary Ganzfeld photostimulator controlled flicker stimulations at seven light levels (-2.7 to 2 log cd/m2) and five frequencies (0.5 to 8Hz). Pupil diameter was measured using a high-resolution eyetracker. Three kinds of sinusoidal photoreceptor modulations were generated using silent substitution: 1) rod modulation, 2) cone modulation, and 3) combined rod and cone modulation in phase (Experiment 1) or phase shifted (Experiment 2) from a fixed rod phase. The melanopsin excitation was computed for each condition. A vector sum model was used to estimate the relative contribution of rods, cones and melanopsin to the pupil response. Results: From Experiment 1, the pupil frequency response peaked at 1Hz at two mesopic light levels for the three modulation conditions. Analyzing the rod-cone phase difference for the combined modulations (Experiment 2) identified a V-shaped response amplitude with a minimum between 135° and 180°. The pupil response phases increased as cone modulation phase increased. The pupil amplitude increased with increasing light level for cone and combined in-phase rod and cone modulation, but not for the rod modulation. Conclusions: These results demonstrate that cone- and rod-pathway contributions are more predominant than melanopsin contribution to the phasic pupil response. The combined rod, cone and melanopsin inputs to the phasic state of the pupil light reflex follow linear summation.
dc.format application/pdf
dc.language.iso eng
dc.publisher Association for Research in Vision and Ophthalmology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.subject melanopsin
dc.subject flicker
dc.subject silent-substitution
dc.subject pupil light reflex
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Assessing Rod, Cone, and Melanopsin Contributions to Human Pupil Flicker Responses
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion 2017-01-24T18:32:04Z
dc.identifier.eissn 1552-5783
dc.journal.volume 55
dc.journal.number 2
dc.journal.pagination 719-727
dc.journal.pais Estados Unidos
dc.journal.ciudad Rockville
dc.description.fil Fil: Barrionuevo, Pablo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucuman. Instituto de Investigacion En Luz, Ambiente y Vision; Argentina. University Of Illinois; Estados Unidos
dc.description.fil Fil: Nicandro, Nathaniel. University Of Illinois; Estados Unidos
dc.description.fil Fil: McAnany, J. Jason. University Of Illinois; Estados Unidos
dc.description.fil Fil: Zele, Andrew J.. University Of Queensland; Australia
dc.description.fil Fil: Gamlin, Paul. University Of Alabama At Birmingahm; Estados Unidos
dc.description.fil Fil: Cao, Dingcai. University Of Illinois; Estados Unidos
dc.journal.title Investigative Ophthalmology & Visual Science
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/

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