Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents

Delgado, Fermin; Nicova, Eva; Agotegaray, Mariela AlejandraIcon ; González Pardo, María VerónicaIcon ; Dorn, VivianaIcon ; Burrow, Robert A.; Dennehy, Mariana
Fecha de publicación: 01/08/2019
Editorial: Elsevier Science SA
Revista: Inorganica Chimica Acta
ISSN: 0020-1693
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Inorgánica y Nuclear; Química Orgánica; Biología Celular, Microbiología

Resumen

This report describes the synthesis and characterization of two nickel thiosaccharinate complexes, [Ni(tsac)2(PPh3)2] (1) and [Ni(tsac)2(dppe)]·CH3CN (2), where tsac = thiosaccharinate anion, PPh3 = triphenylphosphane and dppe = bis(diphenylphosphanyl)ethane. Elemental analysis, FTIR, 1H, 13C and 31P NMR spectra and single crystal X ray diffraction studies of the complexes are presented. DFT optimizations of the two new compounds were performed in order to verify the FTIR vibrational assignations. The two nickel(II) thiosaccharinate complexes consist of mononuclear units in which the Ni atoms are the centre of square-planar coordination spheres, surrounded by two sulfur thiosaccharinate atoms and two phosphorous atoms from the phosphane ligands. In both complexes, the anions are mono-coordinated to the metal. In the [Ni(tsac)2(PPh3)2] structure, the phosphane moieties are located in trans position. In the [Ni(tsac)2(dppe)] structure, the dppe ligand chelates to the metal centre, as expected. Additionally, the superoxide dismutase (SOD) mimetic activity of the complexes was measured and it is reported herein. The effects of the complexes on cell proliferation were also studied and are described.
Palabras clave: CELL PROLIFERATION INHIBITION , CRYSTALLINE STRUCTURE , NICKEL , PHOSPHANE , SUPEROXIDE DISMUTASE MIMETIC ACTIVITY , THIONES
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 1.285Mb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/120069
URL: https://www.sciencedirect.com/science/article/abs/pii/S002016931930341X
DOI: http://dx.doi.org/10.1016/j.ica.2019.04.040
Colecciones
Articulos(INBIOSUR)
Articulos de INSTITUTO DE CIENCIAS BIOLOGICAS Y BIOMEDICAS DEL SUR
Articulos(INQUISUR)
Articulos de INST.DE QUIMICA DEL SUR
Citación
Delgado, Fermin; Nicova, Eva; Agotegaray, Mariela Alejandra; González Pardo, María Verónica; Dorn, Viviana; et al.; Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents; Elsevier Science SA; Inorganica Chimica Acta; 494; 1-8-2019; 55-64
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES