Artículo
SLPI in the perfusion solution helps to identify graft quality in kidney transplants
Ambrosi, Nella Gabriela
; Caro, Fiorella Yanina
; Osella, Francisco; Alvarez, Leonardo Diaz; Sánchez, Francisco
; Toniolo, Fernanda; Guerrieri, Diego
; Incardona, Claudio; Casadei, Domingo; Chuluyan, Hector Eduardo
Fecha de publicación:
08/2019
Editorial:
Future Medicine
Revista:
Biomarkers In Medicine
ISSN:
1752-0363
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aim: It is important to find biomarkers that identify the graft quality in kidney transplantation. Results & methodology: The level of SLPI in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delayed graft function or rejection episodes in post-trasplant, had higher SLPI concentrations in the perfusion solution than patients without delayed graft function or rejections. Furthermore, SLPI could discriminate between patients with better or worse estimated glomerular filtration rate among low-risk patients (kidney donor profile index <80). Discussion & conclusion: These results suggest that the SLPI concentration in the perfusion solutions could be a predictor of short-term organ function and a complement to the kidney donor profile index score.
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Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Ambrosi, Nella Gabriela; Caro, Fiorella Yanina; Osella, Francisco; Alvarez, Leonardo Diaz; Sánchez, Francisco; et al.; SLPI in the perfusion solution helps to identify graft quality in kidney transplants; Future Medicine; Biomarkers In Medicine; 13; 11; 8-2019; 895-906
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