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dc.contributor.author
Coelho, Miguel B.
dc.contributor.author
Attig, Jan
dc.contributor.author
Bellora, Nicolás

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König, Julian
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Hallegger, Martina
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Kayikci, Melis
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Eyras, Eduardo
dc.contributor.author
Ule, Jernej
dc.contributor.author
Smith, Christopher W. J.
dc.date.available
2017-01-26T15:32:18Z
dc.date.issued
2015-01
dc.identifier.citation
Coelho, Miguel B.; Attig, Jan; Bellora, Nicolás; König, Julian; Hallegger, Martina; et al.; Nuclear matrix protein Matrin 3 regulates alterna tive splicing and forms overlapping regulatory networks with PTB; Nature Publishing Group; Embo Journal; 34; 5; 1-2015; 653-668
dc.identifier.issn
0261-4189
dc.identifier.uri
http://hdl.handle.net/11336/11980
dc.description.abstract
Matrin3 is an RNA‐ and DNA‐binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no widespread role in RNA metabolism has yet been clearly demonstrated. We identified Matrin3 by its interaction with the second RRM domain of the splicing regulator PTB. Using a combination of RNAi knockdown, transcriptome profiling and iCLIP, we find that Matrin3 is a regulator of hundreds of alternative splicing events, principally acting as a splicing repressor with only a small proportion of targeted events being co‐regulated by PTB. In contrast to other splicing regulators, Matrin3 binds to an extended region within repressed exons and flanking introns with no sharply defined peaks. The identification of this clear molecular function of Matrin3 should help to clarify the molecular pathology of ALS and other diseases caused by mutations of Matrin3.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group

dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alternative Splicing
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Matrin3
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Ptb
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Regulatory Motifs
dc.subject.classification
Bioquímica y Biología Molecular

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Ciencias Biológicas

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CIENCIAS NATURALES Y EXACTAS

dc.title
Nuclear matrix protein Matrin 3 regulates alterna tive splicing and forms overlapping regulatory networks with PTB
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-12T14:22:10Z
dc.journal.volume
34
dc.journal.number
5
dc.journal.pagination
653-668
dc.journal.pais
Reino Unido

dc.journal.ciudad
Londres
dc.description.fil
Fil: Coelho, Miguel B.. University of Cambridge; Reino Unido
dc.description.fil
Fil: Attig, Jan. UCL Institute of Neurology; Reino Unido. MRC-Laboratory of Molecular Biology; Reino Unido
dc.description.fil
Fil: Bellora, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Patagonia Norte. Instituto de Investigación En Biodiversidad y Medioambiente; Argentina. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España. Universidad Nacional del Comahue; Argentina
dc.description.fil
Fil: König, Julian. MRC-Laboratory of Molecular Biology; Reino Unido
dc.description.fil
Fil: Hallegger, Martina. University of Cambridge; Reino Unido. UCL Institute of Neurology; Reino Unido
dc.description.fil
Fil: Kayikci, Melis. MRC-Laboratory of Molecular Biology; Reino Unido
dc.description.fil
Fil: Eyras, Eduardo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España
dc.description.fil
Fil: Ule, Jernej. UCL Institute of Neurology; Reino Unido
dc.description.fil
Fil: Smith, Christopher W. J.. University of Cambridge; Reino Unido
dc.journal.title
Embo Journal

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://emboj.embopress.org/content/34/5/653
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365034/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.15252/embj.201489852
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