Artículo
A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia
Simonovich, Ventura A.; Burgos Pratx, Leandro D.; Scibona, Paula; Beruto, Maria Valeria; Vallone, Miguel Gabriel; Vázquez, C.; Savoy, N.; Giunta, Diego Hernan; Pérez, L.G.; Sánchez, M.L.; Gamarnik, Andrea Vanesa
; Ojeda, D.S.; Santoro, D.M.; Camino, P. J.; Antelo, S.; Rainero, K.; Vidiella, G. P.; Miyazaki, E. A.; Cornistein, W.; Trabadelo, O. A.; Ross, F. M.; Spotti, M.; Funtowicz, G.; Scordo, W. E.; Losso, M. H.; Ferniot, I.; Pardo, P. E.; Rodriguez, E.; Rucci, P.; Pasquali, J.; Fuentes, N. A.; Esperatti, M.; Speroni, G. A.; Nannini, Esteban
; Matteaccio, A.; Michelangelo, H.G.; Follmann, D.; Lane, H. Clifford; Belloso, Waldo Horacio
Fecha de publicación:
11/2020
Editorial:
Massachusetts Medical Society
Revista:
New England Journal of Medicine
ISSN:
0028-4793
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
BACKGROUND:Convalescent plasma is frequently administered to patients with Covid-19 and hasbeen reported, largely on the basis of observational data, to improve clinical outcomes.Minimal data are available from adequately powered randomized, controlled trials.
METHODS:We randomly assigned hospitalized adult patients with severe Covid-19 pneumoniain a 2:1 ratio to receive convalescent plasma or placebo. The primary outcome wasthe patient?s clinical status 30 days after the intervention, as measured on a six-pointordinal scale ranging from total recovery to death.
RESULTS:A total of 228 patients were assigned to receive convalescent plasma and 105 toreceive placebo. The median time from the onset of symptoms to enrollment inthe trial was 8 days (interquartile range, 5 to 10), and hypoxemia was the mostfrequent severity criterion for enrollment. The infused convalescent plasma had amedian titer of 1:3200 of total SARS-CoV-2 antibodies (interquartile range, 1:800 to1:3200]. No patients were lost to follow-up. At day 30 day, no significant differencewas noted between the convalescent plasma group and the placebo group in thedistribution of clinical outcomes according to the ordinal scale (odds ratio, 0.83(95% confidence interval [CI], 0.52 to 1.35; P=0.46). Overall mortality was 10.96%in the convalescent plasma group and 11.43% in the placebo group, for a risk difference of −0.46 percentage points (95% CI, −7.8 to 6.8). Total SARS-CoV-2 antibodytiters tended to be higher in the convalescent plasma group at day 2 after the intervention. Adverse events and serious adverse events were similar in the two groups.
CONCLUSIONS:no significant differences were observed in clinical status or overall mortality between patients treated with convalescent plasma and those who received placebo.(PlasmAr ClinicalTrials.gov number, NCT04383535.)
Palabras clave:
PLASMA
,
CONVALECIENTE
,
COVID-19
,
SARS-COV-2
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Licencia
Identificadores
Colecciones
Articulos(IDICER)
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Articulos de INSTITUTO DE INMUNOLOGIA CLINICA Y EXPERIMENTAL DE ROSARIO
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Simonovich, Ventura A.; Burgos Pratx, Leandro D.; Scibona, Paula; Beruto, Maria Valeria; Vallone, Miguel Gabriel; et al.; A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia; Massachusetts Medical Society; New England Journal of Medicine; 11-2020; 1-11
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