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dc.contributor.author
Gonzalez, Jimena Soledad
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dc.contributor.author
Mijangos Ugarte, Carmen
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dc.contributor.author
Hernandez, Rebeca
dc.date.available
2020-12-02T18:34:16Z
dc.date.issued
2019-04
dc.identifier.citation
Gonzalez, Jimena Soledad; Mijangos Ugarte, Carmen; Hernandez, Rebeca; Polysaccharide coating of gelatin gels for controlled BSA release; MDPI AG; Polymers; 11; 4; 4-2019
dc.identifier.issn
2073-4360
dc.identifier.uri
http://hdl.handle.net/11336/119653
dc.description.abstract
Self-assembly of natural polymers constitute a powerful route for the development of functional materials. In particular, layer-by-layer (LBL) assembly constitutes a versatile technique for the nanostructuration of biobased polymers into multilayer films. Gelatin has gained much attention for its abundance, biodegradability, and excellent gel-forming properties. However, gelatin gels melt at low temperature, thus limiting its practical application. With respect to the above considerations, here, we explored the potential application of gelatin gels as a matrix for protein delivery at physiological temperature. A model protein, bovine serum albumin (BSA), was encapsulated within gelatin gels and then coated with a different number of bilayers of alginate and chitosan (10, 25, 50) in order to modify the diffusion barrier. The coated gel samples were analyzed by means of Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) and confocal Raman spectroscopy, and it was found that the multilayer coatings onto polymer film were interpenetrated to some extent within the gelatin. The obtained results inferred that the coating of gelatin gels with polysaccharide multilayer film increased the thermal stability of gelatin gels and modulated the BSA release. Finally, the influence of a number of bilayers onto the drug release mechanism was determined. The Ritger-Peppas model was found to be the most accurate to describe the diffusion mechanism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI AG
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GELATIN GEL
dc.subject
LBL COATING
dc.subject
MULTILAYER FILM
dc.subject
PROTEIN RELEASE
dc.subject.classification
Compuestos
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dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Polysaccharide coating of gelatin gels for controlled BSA release
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-16T20:11:29Z
dc.journal.volume
11
dc.journal.number
4
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Mijangos Ugarte, Carmen. Instituto en Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: Hernandez, Rebeca. Instituto en Ciencia y Tecnología de Polímeros; España
dc.journal.title
Polymers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/11/4/702
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/polym11040702
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