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Artículo

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

de Giusti, Verónica CelesteIcon ; Caldiz, Claudia IrmaIcon ; Ennis, Irene LuciaIcon ; Perez, Nestor GustavoIcon ; Cingolani, Horacio EugenioIcon ; Aiello, Ernesto AlejandroIcon
Fecha de publicación: 05/2013
Editorial: Frontiers
Revista: Frontiers in Mitochondrail Research
e-ISSN: 1664-042X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signaling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the last years. In our lab, we have been studying the participation of mitochondrial ROS in the intracellular pathways triggered by the renin-angiotensin II-aldosterone system (RAAS) in the myocardium during the past few years. We have demonstrated that acute activation of cardiac RAAS induces mitochondrial ATP-dependent potassium channel (mitoKATP) opening with the consequent enhanced production of mitochondrial ROS. These oxidant molecules, in turn, activate membrane transporters, as sodium/hydrogen exchanger (NHE-1) and sodium/bicarbonate cotransporter (NBC) via the stimulation of the ROS-sensitive MAPK cascade. The stimulation of such effectors leads to an increase in cardiac contractility. In addition, it is feasible to suggest that a sustained enhanced production of mitochondrial ROS induced by chronic cardiac RAAS, and hence, chronic NHE-1 and NBC stimulation, would also result in the development of cardiac hypertrophy.
Palabras clave: Sodium-Hydrogen Antiporter , Reactive Oxygen Species , Second Messenger Systems , Sodium-Bicarbonate Symporters
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/11958
DOI: http://dx.doi.org/10.3389/fphys.2013.00126
URL: http://journal.frontiersin.org/article/10.3389/fphys.2013.00126/full
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667248/
Colecciones
Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
de Giusti, Verónica Celeste; Caldiz, Claudia Irma; Ennis, Irene Lucia; Perez, Nestor Gustavo; Cingolani, Horacio Eugenio; et al.; Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS); Frontiers; Frontiers in Mitochondrail Research; 4; 5-2013; 1-9; 126
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