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dc.contributor.author
Lopera, Yasmin E.
dc.contributor.author
Fantinelli, Juliana Catalina
dc.contributor.author
González Arbeláez, Luisa Fernanda
dc.contributor.author
Rojano, Benjamín
dc.contributor.author
Ríos, José Luis
dc.contributor.author
Schinella, Guillermo
dc.contributor.author
Mosca, Susana Maria
dc.date.available
2017-01-25T20:29:25Z
dc.date.issued
2013-03
dc.identifier.citation
Lopera, Yasmin E.; Fantinelli, Juliana Catalina; González Arbeláez, Luisa Fernanda; Rojano, Benjamín; Ríos, José Luis; et al.; Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats; Hindawi Publishing Corporation; Evidence-based Complementary And Alternative Medicine; 2013; 3-2013; 1-10; 516727
dc.identifier.issn
1741-427X
dc.identifier.uri
http://hdl.handle.net/11336/11948
dc.description.abstract
Our objective was to assess the antioxidant properties and the effects against the reperfusion injury of a nonalcoholic extract obtained by fermentation from the Colombian blueberry, mortino ( Vaccinium meridionale Swartz, Ericaceae). Antioxidant properties were assessed by in vitro systems. To examine the postischemic myocardial function, isolated rat hearts were treated 10 min before ischemia and during the first 10 min of reperfusion with the extract. To analyze the participation of nitric oxide (NO), other experiments were performed in the presence of nitric oxide synthase (NOS) inhibition with NG-nitro-L-arginine methyl ester (L-NAME). In cardiac tissue thiobarbituric acid reactive substances (TBARS) concentration, reduced glutathione (GSH) content, endothelial NOS (eNOS), and Akt expression were also measured. The blueberry extract showed higher total phenols and anthocyanins contents, scavenging activity of superoxide radical and systolic and diastolic function was improved, TBARS diminished, GSH was partially preserved, and both NOS and Akt expression increased in hearts treated with the extract. These beneficial effects were lost when eNOS was inhibited. In resume, these data show that the increase of eNOS expression via Akt and the scavenging activity contribute to the cardioprotection afforded by acute treatment with Colombian blueberry extract against ischemia and reperfusion injury.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Ischemia-Reperfusion
dc.subject
Vaccinium Meridionale Sw
dc.subject
Antioxidant
dc.subject
Nitric Oxidase Synthase
dc.subject.classification
Fisiología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-25T13:58:44Z
dc.identifier.eissn
1741-4288
dc.journal.volume
2013
dc.journal.pagination
1-10; 516727
dc.journal.pais
Egipto
dc.journal.ciudad
El Cairo
dc.description.fil
Fil: Lopera, Yasmin E.. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Fantinelli, Juliana Catalina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: González Arbeláez, Luisa Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Rojano, Benjamín. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Ríos, José Luis. Universidad de Valencia; España
dc.description.fil
Fil: Schinella, Guillermo. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
dc.description.fil
Fil: Mosca, Susana Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.journal.title
Evidence-based Complementary And Alternative Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2013/516727
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ecam/2013/516727/


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