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dc.contributor.author Aiello, Ernesto Alejandro
dc.contributor.author de Giusti, Verónica Celeste
dc.date.available 2017-01-25T20:26:01Z
dc.date.issued 2013-02
dc.identifier.citation Aiello, Ernesto Alejandro; de Giusti, Verónica Celeste; Regulation of the Cardiac Sodium/Bicarbonate cotransporter by Angiotensin II: potential contribution to structural, ionic and electrophysiological Myocardial remodelling; Bentham Science Publishers; Current Cardiology Reviews; 9; 1; 2-2013; 24-32
dc.identifier.issn 1573-403X
dc.identifier.uri http://hdl.handle.net/11336/11945
dc.description.abstract The sodium/ bicarbonate cotransporter (NBC) is, with the Na+ /H+ exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pHi). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na+ per 1molecule of HCO3 - (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na+ per 2 molecules of HCO3 - (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pHi and intracellular Na+ concentration, which indirectly, due to the stimulation of the Na+ /Ca2+ exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca2+ concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca2+ concentration. The regulation of the intracellular Na+ and Ca2+ concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.
dc.format application/pdf
dc.language.iso eng
dc.publisher Bentham Science Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ANGIOTENSIN II
dc.subject CALCIUM OVERLOAD
dc.subject CARDIAC ARRHYTHMIAS
dc.subject CARDIAC HYPERTROPHY
dc.subject.classification Fisiología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Regulation of the Cardiac Sodium/Bicarbonate cotransporter by Angiotensin II: potential contribution to structural, ionic and electrophysiological Myocardial remodelling
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-01-25T13:57:29Z
dc.journal.volume 9
dc.journal.number 1
dc.journal.pagination 24-32
dc.journal.pais Emiratos Árabes Unidos
dc.journal.ciudad Sharjah
dc.description.fil Fil: Aiello, Ernesto Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.description.fil Fil: de Giusti, Verónica Celeste. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
dc.journal.title Current Cardiology Reviews
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/157340313805076340
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/ben/ccr/2013/00000009/00000001/art00005
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584305/


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    Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)