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Artículo

Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses

Chatterjee, Shampa; Fujiwara, Keigi; Perez, Nestor GustavoIcon ; Ushio Fukai, Masuko; Fisher, Aron B.
Fecha de publicación: 06/2015
Editorial: American Physiological Society
Revista: American Journal Of Physiology-heart And Circulatory Physiology
ISSN: 0363-6135
e-ISSN: 1522-1539
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis. This was highlighted at the Pan American Physiological Society meeting at Iguassu Falls, Brazil, in a symposium titled “Mechanosignaling in the Vasculature.” This symposium presented recent research that showed the existence of a vital link between mechanosensing and downstream redox sensitive signaling cascades. This link helps to transduce and transmit the physical force into an observable physiological response. The speakers showcased how mechanosensors such as ion channels, membrane receptor kinases, adhesion molecules, and other cellular components transduce the force via redox signals (such as reactive oxygen species and nitric oxide) to receptors (transcription factors, growth factors, etc.). Receptor activated pathways then lead to cellular responses including cellular proliferation, contraction, and remodeling. These responses have major relevance to the physiology and pathophysiology of various cardiovascular diseases. Thus an understanding of the complex series of events, from the initial sensing through the final response, is essential for progress in this field. Overall, this symposium addressed some important emerging concepts in the field of mechanosignaling and the eventual pathophysiological responses.
Palabras clave: Anrep Effect , Mechanotransduction , Nadph Oxidase , Revascularization , Vasculature
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/11940
DOI: http://dx.doi.org/10.1152/ajpheart.00105.2015
URL: http://ajpheart.physiology.org/content/308/12/H1451
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469874/
Colecciones
Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Citación
Chatterjee, Shampa; Fujiwara, Keigi; Perez, Nestor Gustavo; Ushio Fukai, Masuko; Fisher, Aron B.; Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses; American Physiological Society; American Journal Of Physiology-heart And Circulatory Physiology; 308; 12; 6-2015; 1451-1462
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