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dc.contributor.author
Arce, Maria Elena
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dc.contributor.author
Sanchez, Susana Ines
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dc.contributor.author
Correa, María Milagros
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dc.contributor.author
Ciuffo, Gladys Maria
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dc.date.available
2020-11-27T14:52:53Z
dc.date.issued
2019-02
dc.identifier.citation
Arce, Maria Elena; Sanchez, Susana Ines; Correa, María Milagros; Ciuffo, Gladys Maria; Age-Related Changes in Ang II Receptor Localization and Expression in the Developing Auditory Pathway; Springer/Plenum Publishers; Neurochemical Research; 44; 2; 2-2019; 412-420
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/119216
dc.description.abstract
We studied Ang II receptor localization in different nuclei of the auditory system, by means of binding autoradiography,during brain development. The inferior colliculus (IC), a large midbrain structure which serves as an obligatory synaptic station in both the ascending and descending auditory pathways, exhibited high Ang II AT2 binding at all ages (P0, P8,P15, P30), being maximal at P15. These observations were confirmed by in situ hybridization and immunofluorescence at P15, demonstrating that AT2 receptor mRNA localized at the same area recognized by AT2 antibodies and anti β III?tubulin suggesting the neuronal nature of the reactive cells. Ang II AT1 receptors were absent at early developmental ages (P0) in all nuclei of the auditory system and a low level was observed in the IC at the age P8. AT2 receptors were present at ventral cochlear nucleus and superior olivary complex, being higher at P15 and P8, respectively. We also explored the effect ofprenatal administration of Ang II or PD123319 (AT2 antagonist) on binding of Ang II receptors at P0, P8, P15. Both treatments increased significantly the level of AT2 receptors at P0 and P8 in the IC. Although total binding in the whole IC from P15 animals showed no difference between treatments, the central nucleus of the IC exhibited higher binding. Our results supports a correlation between the timing of the higher expression of Ang II AT2 receptors in different nuclei, the onset of audition and the establishment of neuronal circuits of the auditory pathway.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AT2 RECEPTORS
dc.subject
INFERIOR COLLICULUS
dc.subject
SUPERIOR OLIVARY COMPLEX
dc.subject
COCHLEAR NUCLEUS
dc.subject
BRAIN DEVELOPMENT
dc.subject.classification
Biología del Desarrollo
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Age-Related Changes in Ang II Receptor Localization and Expression in the Developing Auditory Pathway
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-18T20:47:52Z
dc.identifier.eissn
1573-6903
dc.journal.volume
44
dc.journal.number
2
dc.journal.pagination
412-420
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Arce, Maria Elena. Universidad Nacional de San Luis; Argentina
dc.description.fil
Fil: Sanchez, Susana Ines. Universidad Nacional de San Luis; Argentina
dc.description.fil
Fil: Correa, María Milagros. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Ciuffo, Gladys Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.journal.title
Neurochemical Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11064-018-2687-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11064-018-2687-4
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