Artículo
Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering
Galdopórpora, Juan Manuel; Pérez, Claudio Javier
; Tuttolomondo, María Victoria
; Desimone, Martín Federico
Fecha de publicación:
14/02/2019
Editorial:
VBRI Press
Revista:
Advanced Materials Letters
ISSN:
0976-397X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The main objective of this study is to develop an economic, environmentally friendly and malleable biomaterial for tissue engineering applications. Water and glycerol have been used as solvents for the gelatin hydrogel synthesis. This solvent mixture led to a biomaterial with improved thermal properties. Indeed, a 16 °C increase in thermal transition temperature was achieved. Furthermore, to enhance mechanical properties, riboflavin was used as a crosslinking agent. Chemical crosslinking step was initiated with UV radiation to obtain riboflavin radical polymerization of gelatin chains, hence, rheological properties of gelatin hydrogel were improved. Thus, Gelatin-UV-Riboflavin hydrogel showed good swelling and increased mechanical properties, obtaining a novel material for drug delivery and medical purposes.
Palabras clave:
BIOPOLYMER
,
CROSSLINKING
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Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Galdopórpora, Juan Manuel; Pérez, Claudio Javier; Tuttolomondo, María Victoria; Desimone, Martín Federico; Riboflavin-UVA gelatin crosslinking: Design of a biocompatible and thermo-responsive biomaterial with enhanced mechanical properties for tissue engineering; VBRI Press; Advanced Materials Letters; 10; 5; 14-2-2019; 324-328
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