Artículo
Photochemistry of tyrosine dimer: when an oxidative lesion of proteins is able to photoinduce further damage
Reid, Lara Olivia
; Vignoni, Mariana
; Martins Froment, Nathalie; Thomas, Andrés Héctor
; Dantola, Maria Laura
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Fecha de publicación:
04/2019
Editorial:
Royal Society of Chemistry
Revista:
Photochemical and Photobiological Sciences
ISSN:
1474-905X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The tyrosine dimer (Tyr2), a covalent bond between two tyrosines (Tyr), is one of the most important modifications of the oxidative damage of proteins. This compound is increasingly used as a marker of aging, stress and pathogenesis. At physiological pH, Tyr2 is able to absorb radiation at wavelengths significantly present in the solar radiation and artificial sources of light. As a result, when Tyr2 is formed in vivo, a new chromophore appears in the proteins. Despite the biomedical importance of Tyr2, the information of its photochemical properties is limited due to the drawbacks of its synthesis. Therefore, in this work we demonstrate that at physiological pH, Tyr2 undergoes oxidation upon UV excitation yielding different products which conserve the dimeric structure. During its photodegradation different reactive oxygen species, like hydrogen peroxide, superoxide anion and singlet oxygen, are produced. Otherwise, we demonstrated that Tyr2 is able to sensitize the photodegradation of tyrosine. The results presented in this work confirm that Tyr2 can act as a potential photosensitizer, contributing to the harmful effects of UV-A radiation on biological systems.
Palabras clave:
tyrosine dimer
,
photodegradation
,
reactive oxygen species
,
photosensitizer
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Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Reid, Lara Olivia; Vignoni, Mariana; Martins Froment, Nathalie; Thomas, Andrés Héctor; Dantola, Maria Laura; Photochemistry of tyrosine dimer: when an oxidative lesion of proteins is able to photoinduce further damage; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 18; 7; 4-2019; 1732-1741
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