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dc.contributor.author
Zarrintaj, Payam  
dc.contributor.author
Jouyandeh, Maryam  
dc.contributor.author
Reza Ganjali, Mohammad  
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Shirkavand Hadavand, Behzad  
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Mozafari, Masoud  
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Sheiko, Sergei S.  
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Vatankhah Varnoosfaderani, Mohammad  
dc.contributor.author
Gutiérrez Carmona, Tomy José  
dc.contributor.author
Reza Saeb, Mohammad  
dc.date.available
2020-11-24T18:09:48Z  
dc.date.issued
2019-08  
dc.identifier.citation
Zarrintaj, Payam ; Jouyandeh, Maryam ; Reza Ganjali, Mohammad ; Shirkavand Hadavand, Behzad ; Mozafari, Masoud ; et al.; Thermo-sensitive polymers in medicine: A review; Pergamon-Elsevier Science Ltd; European Polymer Journal; 117; 8-2019; 402-423  
dc.identifier.issn
0014-3057  
dc.identifier.uri
http://hdl.handle.net/11336/118913  
dc.description.abstract
A wide variety of smart polymer systems such as thermosensitive polymers (TSPs)have been developed and applied mimicking nature. TSPs are a class of macromolecules that exhibit bio-inspired behavior and have various applications such as drug delivery, tissue engineering, theranostic particles and bioseparation. An inherent feature of a living system is its ability to react in response to an external stimulus. The temperature dependence of polymer properties is the reason behind dramatic changes in morphology, solubility, shape and sol-gel transition. TSPs can be synthesized as hydrogel, micro- and nanoparticles, film, micelle and mussel-inspired materials. The architecture of TSPs determines their biomimetic patterns and allows one to expand their uses. TSPs can be used as systems for the controlled release of drugs to a specific organ, as well as scaffolds in tissue engineering. Multi-responsive and thermosensitive features of TSPs give rise to design of smart systems for special applications. For example, pH- and photo-responsive abilities in combination with temperature sensitivity can play a vital role in drug delivery and tissue engineering. In-depth knowledge about the structure-property relationship is a key factor to design a smart biomimetic polymer. In this review paper, the functional design of the TSPs, their biomedical applications and the road ahead for their developments are comprehensively overviewed.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
DRUG DELIVERY  
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HYDROGEL  
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STIMULI-RESPONSIVE  
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TEMPERATURE-RESPONSIVE POLYMER  
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TEMPERATURE-SENSITIVE POLYMER  
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TISSUE ENGINEERING  
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Compuestos  
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Ingeniería de los Materiales  
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INGENIERÍAS Y TECNOLOGÍAS  
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Físico-Química, Ciencia de los Polímeros, Electroquímica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Thermo-sensitive polymers in medicine: A review  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-18T16:45:18Z  
dc.journal.volume
117  
dc.journal.pagination
402-423  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Zarrintaj, Payam. Urmia University; Irán. Amirkabir University Of Technology; Irán  
dc.description.fil
Fil: Jouyandeh, Maryam. University Of Tehran; Irán  
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Fil: Reza Ganjali, Mohammad. Biosensor Research Center; Irán. University Of Tehran; Irán  
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Fil: Shirkavand Hadavand, Behzad. Institute For Color Science And Technology; Irán  
dc.description.fil
Fil: Mozafari, Masoud. Iran University Of Medical Sciences; Irán  
dc.description.fil
Fil: Sheiko, Sergei S.. University of North Carolina; Estados Unidos  
dc.description.fil
Fil: Vatankhah Varnoosfaderani, Mohammad. University of North Carolina; Estados Unidos  
dc.description.fil
Fil: Gutiérrez Carmona, Tomy José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina  
dc.description.fil
Fil: Reza Saeb, Mohammad. Institute For Color Science And Technology; Irán. University Of Tehran; Irán  
dc.journal.title
European Polymer Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.eurpolymj.2019.05.024  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0014305719303507?via%3Dihub