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Artículo

Evidence of the effectiveness of Resveratrol in the prevention of guanine one-electron oxidation: possible benefits in cancer prevention

Neyra Recky, Jael RhodeIcon ; Gaspar Tosato, MairaIcon ; Serrano, Mariana PaulaIcon ; Thomas, Andrés HéctorIcon ; Dántola, M. Laura; Lorente, CarolinaIcon
Fecha de publicación: 06/2019
Editorial: Royal Society of Chemistry
Revista: Physical Chemistry Chemical Physics
ISSN: 1463-9076
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Orgánica

Resumen

Over the past few years, the interest in Resveratrol (3,4′,5,-trihydroxystilbene, RSV) has increased due to the evidence found of its antioxidant action that protects biomolecules and cells from oxidative damage. The interest has been further exacerbated by the natural presence of RSV in some fruits and derivatives, especially in red wine. In this paper we present evidence of RSV capacity in protecting a deoxynucleotide, an essential constituent of DNA, from one-electron oxidation. This article evaluates the mechanism responsible for the antioxidant action of RSV, after one-electron oxidation of 2′-deoxyguanosine 5′-monophosphate (dGMP), by kinetic analysis during steady-state irradiation and laser flash photolysis experiments. Results showed that RSV protects dGMP by recovering the nucleotide from its radical, which is formed after the reaction of dGMP with the triplet excited state of the photosensitizer. In the absence of RSV, dGMP is irremediably oxidized, and if the damage occurs in dGMP located in DNA molecules, the consequences can be as serious as mutations and subsequent carcinogenic lesions.
Palabras clave: resveratrol , antioxidants , laser flash photolysis
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/118713
URL: http://pubs.rsc.org/en/Content/ArticleLanding/2019/CP/C9CP03027A
DOI: https://doi.org/10.1039/C9CP03027A
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Articulos(INIFTA)
Articulos de INST.DE INV.FISICOQUIMICAS TEORICAS Y APLIC.
Citación
Neyra Recky, Jael Rhode; Gaspar Tosato, Maira; Serrano, Mariana Paula; Thomas, Andrés Héctor; Dántola, M. Laura; et al.; Evidence of the effectiveness of Resveratrol in the prevention of guanine one-electron oxidation: possible benefits in cancer prevention; Royal Society of Chemistry; Physical Chemistry Chemical Physics; 21; 29; 6-2019; 16190-16197
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