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dc.contributor.author
Diaz, Carolina
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dc.contributor.author
Neubauer, Stefanie
dc.contributor.author
Rechenmacher, Florian
dc.contributor.author
Kessler, Horst
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dc.contributor.author
Missirlis, Dimitris
dc.date.available
2020-11-19T14:32:13Z
dc.date.issued
2019-11
dc.identifier.citation
Diaz, Carolina; Neubauer, Stefanie; Rechenmacher, Florian; Kessler, Horst; Missirlis, Dimitris; Recruitment of integrin α ν β 3 to integrin α 5 β 1 -induced clusters enables focal adhesion maturation and cell spreading; Company of Biologists; Journal of Cell Science; 133; 11-2019; 1-14
dc.identifier.issn
0021-9533
dc.identifier.uri
http://hdl.handle.net/11336/118650
dc.description.abstract
The major fibronectin (FN)-binding α5β1 and αvβ3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved. Exploiting mechanically tunable nano-patterned substrates, and peptidomimetic ligands designed to selectively bind corresponding integrins, we report that focal adhesions (FAs) of endothelial cells assembled on α5β1 integrin-selective substrates rapidly recruit αvβ3 integrins, but not vice versa. Blocking of αvβ3 integrin hindered FA maturation and cell spreading on α5β1 integrin-selective substrates, indicating a mechanism dependent on extracellular ligand binding and highlighting the requirement of αvβ3 integrin engagement for efficient adhesion. Recruitment of αvβ3 integrins additionally occurred on hydrogel substrates of varying mechanical properties, above a threshold stiffness that supports FA formation. Mechanistic studies revealed the need for soluble factors present in serum to allow recruitment, and excluded exogenous, or endogenous, FN as the ligand responsible for αvβ3 integrin accumulation to adhesion clusters. Our findings highlight a novel mechanism of integrin cooperation and a critical role for αvβ3 integrins in promoting cell adhesion on α5β1 integrin-selective substrates.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Company of Biologists
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
FIBRONECTIN
dc.subject
MECHANOSENSING
dc.subject
CELL ADHESION
dc.subject
ENDOTHELIAL CELLS
dc.subject
NANO-STRUCTURED SUBSTRATES
dc.subject
HYDROGELS
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Recruitment of integrin α ν β 3 to integrin α 5 β 1 -induced clusters enables focal adhesion maturation and cell spreading
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-17T16:37:46Z
dc.journal.number
133
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Diaz, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Max Planck Institute for Medical Research; Alemania
dc.description.fil
Fil: Neubauer, Stefanie. Technische Universitat Munchen. Fakultat Fur Chemie; Alemania
dc.description.fil
Fil: Rechenmacher, Florian. Technische Universitat Munchen. Fakultat Fur Chemie; Alemania
dc.description.fil
Fil: Kessler, Horst. Technische Universitat Munchen. Fakultat Fur Chemie; Alemania
dc.description.fil
Fil: Missirlis, Dimitris. Max Planck Institute for Medical Research; Alemania. Ruprecht Karls Universitat Heidelberg.; Alemania
dc.journal.title
Journal of Cell Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jcs.biologists.org/lookup/doi/10.1242/jcs.232702
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1242/jcs.232702
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