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dc.contributor.author
Theune, Loryn E.
dc.contributor.author
Buchmann, Jens
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Wedepohl, Stefanie
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Molina, María Alejandra
dc.contributor.author
Laufer, Jan
dc.contributor.author
Calderón, Marcelo
dc.date.available
2020-11-18T15:22:47Z
dc.date.issued
2019-10
dc.identifier.citation
Theune, Loryn E.; Buchmann, Jens; Wedepohl, Stefanie; Molina, María Alejandra; Laufer, Jan; et al.; NIR- and thermo-responsive semi-interpenetrated polypyrrole nanogels for imaging guided combinational photothermal and chemotherapy; Elsevier Science; Journal of Controlled Release; 311-312; 10-2019; 147-161
dc.identifier.issn
0168-3659
dc.identifier.uri
http://hdl.handle.net/11336/118619
dc.description.abstract
Versatile, multifunctional nanomaterials for theranostic approaches in cancer treatment are highly on demand in order to increase therapeutic outcomes. Here, we developed thermo-responsive nanogels equipped with the efficient near-infrared (NIR) transducing polymer polypyrrole (PPY) for combinational photothermal and chemotherapeutic therapy along with photoacoustic imaging ability. Long-term stability and water-dispersibility of PPY was achieved using semi-interpenetration method for in situ polymerization of PPY into hydrophilic thermo-responsive nanogels. The semi-interpenetrated nanogels of spherical shape and with hydrodynamic sizes of around 200 nm retained the temperature response behaviour and exhibit excellent photothermal transducing abilities in the NIR region. The PPY nanogels served as photoacoustic contrast agents, which allowed determination of biodistribution profiles ex vivo. In addition, we developed a new method for biodistribution determination based on the photothermal response of the nanogels with an accuracy down to 12.5 μg/mL. We examined the ability of the nanogels as photothermal agents and drug delivery systems in vitro and in vivo. We showed that they efficiently inhibit tumor growth with combinational effects of chemotherapeutics and photothermal treatment. Our work encourages further exploration of nanogels as functional stabilizing matrix for photothermal transducers and their application as drug delivery devices in combination with photothermal therapy and imaging.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NANOGELS
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THERMO-RESPONSIVE POLYMERS
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DRUG DELIVERY
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PHOTOTHERMAL TREATMENT
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
NIR- and thermo-responsive semi-interpenetrated polypyrrole nanogels for imaging guided combinational photothermal and chemotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-08-04T15:09:56Z
dc.journal.volume
311-312
dc.journal.pagination
147-161
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Theune, Loryn E.. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Buchmann, Jens. Martin-universität Halle-wittenberg; Alemania
dc.description.fil
Fil: Wedepohl, Stefanie. Freie Universität Berlin; Alemania
dc.description.fil
Fil: Molina, María Alejandra. Freie Universität Berlin; Alemania. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; Argentina
dc.description.fil
Fil: Laufer, Jan. Martin-universität Halle-wittenberg; Alemania
dc.description.fil
Fil: Calderón, Marcelo. Freie Universität Berlin; Alemania
dc.journal.title
Journal of Controlled Release
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jconrel.2019.08.035
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S016836591930519X
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