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dc.contributor.author
Sedova, Ksenia A.
dc.contributor.author
Bernikova, Olesya G.
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dc.contributor.author
Cuprova, Julia I.
dc.contributor.author
Ivanova, Alexandra D.
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dc.contributor.author
Kutaeva, Galina A.
dc.contributor.author
Pliss, Michael G.
dc.contributor.author
Lopatina, Ekaterina V.
dc.contributor.author
Vaykshnorayte, Marina A.
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dc.contributor.author
Diez, Emiliano Raúl
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dc.contributor.author
Azarov, Jan E.
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dc.date.available
2020-11-16T20:24:58Z
dc.date.issued
2019-12-15
dc.identifier.citation
Sedova, Ksenia A.; Bernikova, Olesya G.; Cuprova, Julia I.; Ivanova, Alexandra D.; Kutaeva, Galina A.; et al.; Association between antiarrhythmic, electrophysiological and antioxidative effects of melatonin in ischemia/reperfusion; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 20; 24; 15-12-2019; 1-15
dc.identifier.issn
1661-6596
dc.identifier.uri
http://hdl.handle.net/11336/118464
dc.description.abstract
Melatonin is assumed to confer cardioprotective action via antioxidative properties. We evaluated the association between ventricular tachycardia and/or ventricular fibrillation (VT/VF) incidence, oxidative stress, and myocardial electrophysiological parameters in experimental ischemia/reperfusion under melatonin treatment. Melatonin was given to 28 rats (10 mg/kg/day, orally, for 7 days) and 13 animals received placebo. In the anesthetized animals, coronary occlusion was induced for 5 min followed by reperfusion with recording of unipolar electrograms from ventricular epicardium with a 64-lead array. Effects of melatonin on transmembrane potentials were studied in ventricular preparations of 7 rats in normal and ?ischemic? conditions. Melatonin treatment was associated with lower VT/VF incidence at reperfusion, shorter baseline activation times (ATs), and activation-repolarization intervals and more complete recovery of repolarization times (RTs) at reperfusion (less baseline-reperfusion difference, ΔRT) (p < 0.05). Superoxide dismutase (SOD) activity was higher in the treated animals and associated with ΔRT (p = 0.001), whereas VT/VF incidence was associated with baseline ATs (p = 0.020). In vitro, melatonin led to a more complete restoration of action potential durations and resting membrane potentials at reoxygenation (p < 0.05). Thus, the antioxidative properties of melatonin were associated with its influence on repolarization duration, whereas the melatonin-related antiarrhythmic effect was associated with its oxidative stress-independent action on ventricular activation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MELATONIN
dc.subject
ISCHEMIA
dc.subject
REPERFUSION
dc.subject
ARRHYTHMIA
dc.subject.classification
Fisiología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Association between antiarrhythmic, electrophysiological and antioxidative effects of melatonin in ischemia/reperfusion
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-08-04T19:37:31Z
dc.identifier.eissn
1422-0067
dc.journal.volume
20
dc.journal.number
24
dc.journal.pagination
1-15
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Sedova, Ksenia A.. Czech Technical University In Prague; República Checa
dc.description.fil
Fil: Bernikova, Olesya G.. Ural Branch of Russian Academy of Sciences; Rusia
dc.description.fil
Fil: Cuprova, Julia I.. Czech Technical University In Prague; República Checa
dc.description.fil
Fil: Ivanova, Alexandra D.. Lomonosov Moscow State University; Rusia
dc.description.fil
Fil: Kutaeva, Galina A.. Pitirim Sorokin Syktyvkar State University; Rusia
dc.description.fil
Fil: Pliss, Michael G.. Almazov National Medical Research Centre; Rusia
dc.description.fil
Fil: Lopatina, Ekaterina V.. University of Saint Petersburg; Rusia
dc.description.fil
Fil: Vaykshnorayte, Marina A.. Ural Branch Of Russian Academy Of Sciences; Rusia
dc.description.fil
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Instituto de Fisiologia; Argentina
dc.description.fil
Fil: Azarov, Jan E.. Ural Branch of Russian Academy of Sciences; Rusia. Pitirim Sorokin Syktyvkar State University; Rusia
dc.journal.title
International Journal of Molecular Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/20/24/6331
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms20246331
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