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dc.contributor.author
Converso, Daniela Paola
dc.contributor.author
Taillé, Camille
dc.contributor.author
Carreras, Maria Cecilia
dc.contributor.author
Jaitovich, Ariel
dc.contributor.author
Poderoso, Juan José
dc.contributor.author
Boczkowski, Jorge
dc.date.available
2020-11-16T18:03:05Z
dc.date.issued
2006-12
dc.identifier.citation
Converso, Daniela Paola; Taillé, Camille; Carreras, Maria Cecilia; Jaitovich, Ariel; Poderoso, Juan José; et al.; HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism; Federation of American Societies for Experimental Biology; FASEB Journal; 20; 8; 12-2006; e482-e492
dc.identifier.issn
0892-6638
dc.identifier.uri
http://hdl.handle.net/11336/118439
dc.description.abstract
This study investigated whether inducible HO-1 is targeted to mitochondria and its putative effects on oxidative metabolism in rat liver. Western blot and immune-electron microscopy in whole purified and fractionated organelles showed basal expression of HO-1 protein in both microsomes and mitochondria (inner membrane), accompanied by a parallel HO activity. Inducers of HO-1 increased HO-1 targeting to the inner mitochondrial membrane, which also contained biliverdin reductase, supporting that both enzymes are in the same compartmentalization. Induction of mitochondrial HO-1 was associated with a decrease of mitochondrial heme content and selective reduction of protein expression of cytochrome oxidase (COX) subunit I, which is coded by the mitochondrial genome and synthesized in the mitochondria depending on heme availability; these changes resulted in decreased COX spectrum and activity. Mitochondrial HO-1 induction was also associated with down-regulation of mitochondrial-targeted NO synthase expression and activity, resulting in a reduction of NO-dependent mitochondrial oxidant yield; inhibition of HO-1 activity reverted these effects. In conclusion, we demonstrated for the first time localization of HO-1 protein in mitochondria. It is surmised that mitochondrial HO-1 has important biological roles in regulating mitochondrial heme protein turnover and in protecting against conditions such as hypoxia, neurodegenerative diseases, or sepsis, in which substantially increased mitochondrial NO and oxidant production have been implicated.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Federation of American Societies for Experimental Biology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CYTOCHROME C OXIDASE
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NOS
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OXYGEN CONSUMPTION
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Ciencias Biomédicas Sociales
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-25T19:08:32Z
dc.journal.volume
20
dc.journal.number
8
dc.journal.pagination
e482-e492
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Converso, Daniela Paola. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Taillé, Camille. Inserm; Francia
dc.description.fil
Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Jaitovich, Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Poderoso, Juan José. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Boczkowski, Jorge. Inserm; Francia. Université Paris Diderot - Paris 7; Francia
dc.journal.title
FASEB Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1096/fj.05-4204fje
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.05-4204fje
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