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dc.contributor.author
Cragnolini, Andrea Beatriz
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dc.contributor.author
Lampitella, Giorgia
dc.contributor.author
Virtuoso, Assunta
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Viscovo, Immacolata
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Panetsos, Fivos
dc.contributor.author
Papa, Michele
dc.contributor.author
Cirillo, Giovanni
dc.date.available
2020-11-16T16:55:28Z
dc.date.issued
2020-05
dc.identifier.citation
Cragnolini, Andrea Beatriz; Lampitella, Giorgia; Virtuoso, Assunta; Viscovo, Immacolata; Panetsos, Fivos; et al.; Regional brain susceptibility to neurodegeneration: What is the role of glial cells?; Medknow Publications; Neural Regeneration Research; 15; 5; 5-2020; 838-842
dc.identifier.issn
1673-5374
dc.identifier.uri
http://hdl.handle.net/11336/118426
dc.description.abstract
The main pathological feature of the neurodegenerative diseases is represented by neuronal death that represents the final step of a cascade of adverse/hostile events. Early in the neurodegenerative process, glial cells (including astrocytes, microglial cells, and oligodendrocytes) activate and trigger an insidious neuroinflammatory reaction, metabolic decay, blood brain barrier dysfunction and energy impairment, boosting neuronal death. How these mechanisms might induce selective neuronal death in specific brain areas are far from being elucidated. The last two decades of neurobiological studies have provided evidence of the main role of glial cells in most of the processes of the central nervous system, from development to synaptogenesis, neuronal homeostasis and integration into, highly specific neuro-glial networks. In this mini-review, we moved from in vitro and in vivo models of neurodegeneration to analyze the putative role of glial cells in the early mechanisms of neurodegeneration. We report changes of transcriptional, genetic, morphological, and metabolic activity in astrocytes and microglial cells in specific brain areas before neuronal degeneration, providing evidence in experimental models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Understanding these mechanisms might increase the insight of these processes and pave the way for new specific glia-targeted therapeutic strategies for neurodegenerative disorders.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Medknow Publications
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASTROCYTES
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GLIAL CELLS
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MICROGLIA
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NEURODEGENERATIVE DISEASES
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NEUROINFLAMMATION
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PARKINSON'S DISEASE
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REACTIVE GLIOSIS
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SELECTIVE NEURONAL DEGENERATION
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Regional brain susceptibility to neurodegeneration: What is the role of glial cells?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-11T19:22:59Z
dc.identifier.eissn
1876-7958
dc.journal.volume
15
dc.journal.number
5
dc.journal.pagination
838-842
dc.journal.pais
India
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dc.description.fil
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
dc.description.fil
Fil: Lampitella, Giorgia. Università degli Studi della Campania Luigi Vanvitelli; Italia
dc.description.fil
Fil: Virtuoso, Assunta. Università degli Studi della Campania Luigi Vanvitelli; Italia
dc.description.fil
Fil: Viscovo, Immacolata. Università degli Studi della Campania Luigi Vanvitelli; Italia
dc.description.fil
Fil: Panetsos, Fivos. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Papa, Michele. Università degli Studi della Campania Luigi Vanvitelli; Italia
dc.description.fil
Fil: Cirillo, Giovanni. Università degli Studi della Campania Luigi Vanvitelli; Italia
dc.journal.title
Neural Regeneration Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=838;epage=842;aulast=Cragnolini
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4103/1673-5374.268897
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