Capítulo de Libro
Exploring Protein Conformational Diversity
Título del libro: Computational Methods in Protein Evolution
Monzon, Alexander Miguel; Fornasari, Maria Silvina
; Zea, Diego Javier
; Parisi, Gustavo Daniel
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Otros responsables:
Sikosek, Tobias
Fecha de publicación:
2019
Editorial:
Springer
ISBN:
978-1-4939-8735-1
Idioma:
Inglés
Clasificación temática:
Resumen
The native state of proteins is composed of conformers in dynamical equilibrium. In this chapter, different issues related to conformational diversity are explored using a curated and experimentally based database called CoDNaS (Conformational Diversity in the Native State). This database is a collection of redundant structures for the same sequence. CoDNaS estimates the degree of conformational diversity using different global and local structural similarity measures. It allows the user to explore how structural differences among conformers change as a function of several structural features providing further biological information. This chapter explores the measurement of conformational diversity and its relationship with sequence divergence. Also, it discusses how proteins with high conformational diversity could affect homology modeling techniques.
Palabras clave:
Proteinas
,
Conformaciones
,
Estructura
Archivos asociados
Licencia
Identificadores
Colecciones
Capítulos de libros(SEDE CENTRAL)
Capítulos de libros de SEDE CENTRAL
Capítulos de libros de SEDE CENTRAL
Citación
Monzon, Alexander Miguel; Fornasari, Maria Silvina; Zea, Diego Javier; Parisi, Gustavo Daniel; Exploring Protein Conformational Diversity; Springer; 2019; 353-365
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