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dc.contributor.author
Lores Arnaiz, Silvia
dc.contributor.author
Lombardi, P.
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Karadayian, Analia Graciela
dc.contributor.author
Cutrera, Rodolfo Angel
dc.contributor.author
Bustamante, J.
dc.date.available
2020-11-09T20:49:25Z
dc.date.issued
2019-04
dc.identifier.citation
Lores Arnaiz, Silvia; Lombardi, P.; Karadayian, Analia Graciela; Cutrera, Rodolfo Angel; Bustamante, J.; Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 118; 4-2019; 88-98
dc.identifier.issn
0531-5565
dc.identifier.uri
http://hdl.handle.net/11336/117999
dc.description.abstract
Neuronal ageing is a complex physiological process, associated to metabolic and motor changes. In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor performance and walking footprint pattern. Synaptosomes and mitochondrial fractions were isolated from mouse brain cortex. Active oxygen species and cardiolipin content were measured in both subcellular fractions. Synaptosomal acetylcholinesterase activity was measured in both animal age groups. Results showed that superoxide levels were 42.9% lower in synaptosomes from old mice as compared with young animals, while no changes were observed in non-synaptic mitochondria. Succinate-glutamate dependent H 2 O 2 production rate was 27.5% decreased in non-synaptic mitochondria from aged mice. Cardiolipin content was 21% decreased in synaptosomes from 17-months old animals, while no changes were observed in non-synaptic mitochondria. Acetylcholinesterase activity decreased 16% in 17-months old mice, as compared with young animals. Age-related alterations in neuronal function could be associated with changes in active oxygen species at synapses, with parallel motor deficiencies.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACTIVE OXYGEN SPECIES
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AGEING
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CEREBRAL CORTEX
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MOTOR PERFORMANCE
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NON-SYNAPTIC MITOCHONDRIA
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SYNAPTOSOMES
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-06T20:27:36Z
dc.journal.volume
118
dc.journal.pagination
88-98
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Lores Arnaiz, Silvia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Lombardi, P.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Karadayian, Analia Graciela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Bustamante, J.. Universidad Abierta Interamericana; Argentina
dc.journal.title
Experimental Gerontology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0531556518305035
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.exger.2019.01.012
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