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dc.contributor.author
Genaro, Ana Maria
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Klecha, Alicia Juana
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Frick, Luciana Romina
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Barreiro Arcos, María Laura
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Cremaschi, Graciela Alicia
dc.date.available
2020-11-06T20:50:45Z
dc.date.issued
2009-10
dc.identifier.citation
Genaro, Ana Maria; Klecha, Alicia Juana; Frick, Luciana Romina; Barreiro Arcos, María Laura; Cremaschi, Graciela Alicia; Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations; Bentham Science Publishers; Current Immunology Reviews; 6; 4; 10-2009; 339-347
dc.identifier.issn
1573-3955
dc.identifier.uri
http://hdl.handle.net/11336/117854
dc.description.abstract
The interaction between the immune and the neuroendocrine systems involves, in a bidirectional circuit, shared cellular receptors and their coupled signaling pathways. Disruptions of this circuit lead to pathological situations. Between the endocrine factors, thyroid hormones show to play a role in immunomodulation, maintaining immune system homeostasis in response to stress-mediated immunosuppression. Several experimental evidences showed that hypothyroidism leads to a depression of humoral and cell-mediated immune responses, effects that were reversed by restoration of the euthyroid state. By other hand, chronic stressful situations impair T-cell mediated immunity, affecting the intracellular signals involved in lymphocyte activation. Consequently, a reduction in both T-cell dependent antibody production and lymphocyte function were also described. Besides, a decrease in thyroid hormone serum levels was observed in these conditions. These stress-induced endocrine-immune alterations impact in tumor development, as an enhancement of tumor growth was described in animal models of chronic stress. Interestingly, hormone replacement treatment of chronic stressed animals, which restored the euthyroid status, reversed the observed reduction of T-cell responses improving the outcome of tumor bearing animals. These evidences strengthen the important role that thyroid hormones play in immunomodulation, with a special emphasis in their participation as neuroendocrine regulators of stress-mediated immune deficit.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IMMUNE SYSTEM
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NEUROENDOCRINE SYSTEM
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STRESS
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THYROID HORMONES
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TUMOR
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Thyroid hormone modulation of immunity: Its participation in chronic stress-induced immune alterations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-11T19:45:14Z
dc.journal.volume
6
dc.journal.number
4
dc.journal.pagination
339-347
dc.journal.pais
Emiratos Árabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
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Fil: Klecha, Alicia Juana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
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Fil: Frick, Luciana Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Barreiro Arcos, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Cremaschi, Graciela Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.journal.title
Current Immunology Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/86958/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.2174/1573395511006040339
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