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dc.contributor.author
Carli, Camila B. De A.
dc.contributor.author
De Matos, Djamile C.
dc.contributor.author
Lopes, Flávia C. M.
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Maia, Danielle C. G.
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Dias, Maristela B.
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Sannomiya, Miriam
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Rodrigues, Clenilson M.
dc.contributor.author
Andreo, Marcio A.
dc.contributor.author
Vilegas, Wagner
dc.contributor.author
Colombo, Lucas Luis
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Carlos, Iracilda Z.
dc.date.available
2020-11-06T16:58:35Z
dc.date.issued
2009-01
dc.identifier.citation
Carli, Camila B. De A.; De Matos, Djamile C.; Lopes, Flávia C. M.; Maia, Danielle C. G.; Dias, Maristela B.; et al.; Isolated flavonoids against mammary tumour cells LM2; De Gruyter; Zeitschrift für Naturforschung C. A Journal of Biosciences; 64; 1-2; 1-2009; 32-36
dc.identifier.issn
0939-5075
dc.identifier.uri
http://hdl.handle.net/11336/117821
dc.description.abstract
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
De Gruyter
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ANTITUMOUR ACTIVITY
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CYTOKINE
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FLAVONOIDS
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Isolated flavonoids against mammary tumour cells LM2
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-09-08T14:06:45Z
dc.journal.volume
64
dc.journal.number
1-2
dc.journal.pagination
32-36
dc.journal.pais
Alemania
dc.journal.ciudad
Tübingen
dc.description.fil
Fil: Carli, Camila B. De A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: De Matos, Djamile C.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Lopes, Flávia C. M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Maia, Danielle C. G.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Dias, Maristela B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Sannomiya, Miriam. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Rodrigues, Clenilson M.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Andreo, Marcio A.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Vilegas, Wagner. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil
Fil: Colombo, Lucas Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil
Fil: Carlos, Iracilda Z.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.journal.title
Zeitschrift für Naturforschung C. A Journal of Biosciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/journals/znc/64/1-2/article-p32.xml
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1515/znc-2009-1-206
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