Prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients

Hypersensitivity reaction to abacavir (ABC hypersensitivity syndrome, AHS) is strongly associated with the presence of the HLA-B*57:01 allele. This study was designed to estimate the prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients. We analyzed the presence of HLA-B*57:01 allele in 1646 HIV-1 infected patients from different regions of Argentina. This allele was detected in 81 patients; most of them corresponded to patients living in the central region of the country. The prevalence of HLA-B*57:01 was 4.9%, similar to other Caucasian populations and higher than other data reported for South American populations. This strongly supports screening for the presence of HLA-B*57:01 in abacavir treatment of HIV-1 in our country.

Palabras clave: ABACAVIR , FREQUENCY , HIV-1 , HLA-B*57:01 GENOTYPING , HYPERSENSITIVITY , PHARMACOGENETICS

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/117745

URL: http://onlinelibrary.wiley.com/doi/10.1111/tan.12575/abstract

DOI: http://dx.doi.org/10.1111/tan.12575

Colecciones

Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Moragas, Matías; Belloso, Waldo Horacio; Baquedano, María Sonia; Gutierrez, M. I.; Bissio, E.; et al.; Prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients; Wiley Blackwell Publishing, Inc; Tissue Antigens; 86; 1; 7-2015; 28-31

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