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Artículo

Effects of lipopolysaccharide on neurokinin A content and release in the hypothalamic-pituitary axis

de Laurentiis, AndreaIcon ; Candolfi, MarianelaIcon ; Pisera, Daniel AlbertoIcon ; Seilicovich, AdrianaIcon
Fecha de publicación: 03/2003
Editorial: Elsevier Science
Revista: Regulatory Peptides
ISSN: 0167-0115
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

The administration of bacterial lipopolysaccharide (LPS) markedly affects pituitary secretion, and its effects are probably mediated by cytokines produced by immune cells or by the hypothalamo-pituitary axis itself. Since neurokinin A (NKA) plays a role in inflammatory responses and is involved in the control of prolactin secretion, we examined the in vivo effect of LPS on the concentration of NKA in hypothalamus and pituitary (assessed by RIA) and serum prolactin levels in male rats. One hour after the intraperitoneal administration of LPS (250 μg/rat), NKA content was decreased in the posterior pituitary but not in the hypothalamus or anterior pituitary. Three hours after injection, LPS decreased NKA concentration in the hypothalamus and anterior and posterior pituitary. In all the conditions tested, LPS significantly decreased serum prolactin. We also examined the in vitro effects of LPS (10 μg/ml), interleukin-6 (IL-6, 10 ng/ml) and tumor necrosis factor alpha (TNF-α, 50 ng/ml) on hypothalamic NKA release. Interleukin-6 increased NKA release without modifying hypothalamic NKA concentration, whereas neither LPS nor TNF-α affected them. Our results suggest that IL-6 may be involved in the increase of hypothalamic NKA release induced by LPS. NKA could participate in neuroendocrine responses to endotoxin challenge.
Palabras clave: HYPOTHALAMUS , INTERLEUKIN-6 , PROLACTIN , TACHYKININS , TNF-Α
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/117693
URL: https://www.sciencedirect.com/science/article/abs/pii/S0167011502002586
DOI: https://doi.org/10.1016/S0167-0115(02)00258-6
Colecciones
Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
de Laurentiis, Andrea; Candolfi, Marianela; Pisera, Daniel Alberto; Seilicovich, Adriana; Effects of lipopolysaccharide on neurokinin A content and release in the hypothalamic-pituitary axis; Elsevier Science; Regulatory Peptides; 111; 1-3; 3-2003; 91-95
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