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dc.contributor.author
Gómez Sánchez, Celso E.
dc.contributor.author
Gómez Sánchez, Elise P.
dc.contributor.author
Galigniana, Mario Daniel
dc.contributor.other
Singh, Ajay K.
dc.contributor.other
Williams, Gordon H.
dc.date.available
2020-11-04T13:38:57Z
dc.date.issued
2009
dc.identifier.citation
Gómez Sánchez, Celso E.; Gómez Sánchez, Elise P.; Galigniana, Mario Daniel; Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation; Elsevier; 2009; 329-348
dc.identifier.isbn
978-0-12-373870-7
dc.identifier.uri
http://hdl.handle.net/11336/117581
dc.description.abstract
Steroid hormones bind to and activate intracellular receptors that act as transcription factors that induce the synthesis of specific proteins within the target cells. Aldosterone binds to high-affinity cytoplasmic and nuclear receptors in the kidney and other mineralocorticoid target organs, inducing the synthesis of proteins that mediate the best understood effects of aldosterone. Aldosterone injected intra-arterially or into the renal artery resulted in a decrease in sodium and increased potassium excretion with a delay of 5–30 minutes, with no consistent effect in glomerular filtration rate. Acute subcutaneous administration of aldosterone increases sodium efflux from rat-tail artery smooth muscle due to a specific action on mineralocorticoid receptor (MR). Aldosterone has two types of action on sodium transport: a very rapid increase of passive sodium efflux, insensitive to actinomycin D (inhibitor of transcription), and a delayed stimulation of ouabain-dependent sodium efflux and an ouabain-independent sodium efflux that are completely blocked by actinomycin D. Both the early and late effects were blocked by the spirolactone. These studies indicated that aldosterone had an early, nongenomic effect on sodium transport that was mediated by the MR and a late or classic genomic effect mediated by the MR.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MINERALOCORTICOID RECEPTOR
dc.subject
ALDOSTERONE
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NATRIURESIS
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EFECTOS NO GENOMICOS
dc.subject.classification
Endocrinología y Metabolismo
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-08-24T18:08:28Z
dc.journal.pagination
329-348
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Diego
dc.description.fil
Fil: Gómez Sánchez, Celso E.. G.V. Sonny Montgomery VA Medical Center; Estados Unidos. University of Mississippi; Estados Unidos
dc.description.fil
Fil: Gómez Sánchez, Elise P.. G.V. Sonny Montgomery VA Medical Center; Estados Unidos. University of Mississippi; Estados Unidos
dc.description.fil
Fil: Galigniana, Mario Daniel. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/B978-0-12-373870-7.00022-3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B9780123738707000223
dc.conicet.paginas
522
dc.source.titulo
Textbook of Nephro-Endocrinology
dc.conicet.nroedicion
1ra
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