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dc.contributor.author
Pullara, Filippo
dc.contributor.author
Asciutto, Eliana Karina
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dc.contributor.author
General, Ignacio
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dc.date.available
2020-11-03T13:32:01Z
dc.date.issued
2017-11
dc.identifier.citation
Pullara, Filippo; Asciutto, Eliana Karina; General, Ignacio; Mechanisms of Activation and Subunit Release in Ca2+/Calmodulin-Dependent Protein Kinase II; American Chemical Society; Journal of Physical Chemistry B; 121; 45; 11-2017; 10344-10352
dc.identifier.issn
1520-6106
dc.identifier.uri
http://hdl.handle.net/11336/117487
dc.description.abstract
Calcium/calmodulin-dependent protein kinase II is an enzyme involved in many different functions, including the so-called long-term potentiation, a mechanism that strengthens synapses in a persistent mode and is believed to be a basic cellular mechanism for memory formation. Here we study the conformational changes of the enzyme due to phosphorylation of some key residues that are believed to drive the transition from an inhibited to an active state; it is this active state the one associated with long-term potentiation. We found that the conformational changes could be explained in terms of three charged regions in the three main subdomains of the enzyme: the hub, linker, and kinase. The role of phosphorylation is to change the charge relation between them, turning on and off their interactions and switching between an attractive state (nonphosphorylated or inhibited) and a not attractive one (phosphorylated or active). We also show that phosphorylated subunits become less stable, and this could favor their release from the multimer, as has been already observed experimentally.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Protein
dc.subject
CAMKII
dc.subject.classification
Física Atómica, Molecular y Química
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Mechanisms of Activation and Subunit Release in Ca2+/Calmodulin-Dependent Protein Kinase II
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-02T17:04:52Z
dc.journal.volume
121
dc.journal.number
45
dc.journal.pagination
10344-10352
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Pullara, Filippo. University of Pittsburgh at Johnstown; Estados Unidos
dc.description.fil
Fil: Asciutto, Eliana Karina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: General, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
dc.journal.title
Journal of Physical Chemistry B
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acs.jpcb.7b09214
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.jpcb.7b09214
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