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dc.contributor.author
Invernici, Marcos M.
dc.contributor.author
Furlaneto, Flávia A. C.
dc.contributor.author
Salvador, Sérgio L
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Ouwehand, Arthur C.
dc.contributor.author
Salminen, Seppo
dc.contributor.author
Mantziari, Anastasia
dc.contributor.author
Vinderola, Celso Gabriel
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dc.contributor.author
Ervolino, Edilson
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Santana, Sandro Isaías
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Silva, Pedro Henrique Felix
dc.contributor.author
Messora, Michel R.
dc.date.available
2020-10-28T20:10:57Z
dc.date.issued
2020-09
dc.identifier.citation
Invernici, Marcos M.; Furlaneto, Flávia A. C.; Salvador, Sérgio L; Ouwehand, Arthur C.; Salminen, Seppo; et al.; Bifidobacterium animalis subsp lactis HN019 presents antimicrobial potential against periodontopathogens and modulates the immunological response of oral mucosa in periodontitis patients; Public Library of Science; Plos One; 15; 9; 9-2020; 1-20; e0238425
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/117098
dc.description.abstract
Objective To evaluate the effects of Bifidobacterium animalis subsp. lactis HN019 (HN019) on clinical periodontal parameters (plaque accumulation and gingival bleeding), on immunocompetence of gingival tissues [expression of beta-defensin (BD)-3, toll-like receptor 4 (TLR4), cluster of differentiation(CD)-57 and CD-4], and on immunological properties of saliva (IgA levels) in non-surgical periodontal therapy in generalized chronic periodontitis (GCP) patients. Adhesion to buccal epithelial cells (BEC) and the antimicrobial properties of HN019 were also investigated. Materials and methods Thirty patients were recruited and monitored clinically at baseline (before scaling and root planing-SRP) and after 30 and 90 days. Patients were randomly assigned to Test (SRP +Probiotic, n = 15) or Control (SRP+Placebo, n = 15) group. Probiotic lozenges were used for 30 days. Gingival tissues and saliva were immunologically analyzed. The adhesion of HN019 with or without Porphyromonas gingivalis in BEC and its antimicrobial properties were investigated in in vitro assays. Data were statistically analyzed (p<0.05). Results Test group presented lower plaque index (30 days) and lower marginal gingival bleeding (90 days) when compared with Control group. Higher BD-3, TLR4 and CD-4 expressions were observed in gingival tissues in Test group than in Control group. HN019 reduced the adhesion of P. gingivalis to BEC and showed antimicrobial potential against periodontopathogens. Conclusion Immunological and antimicrobial properties of B. lactis HN019 make it a potential probiotic to be used in non-surgical periodontal therapy of patients with GCP.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bifidobacterium
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Periodontal
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Probiotics
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Alimentos y Bebidas
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Otras Ingenierías y Tecnologías
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Bifidobacterium animalis subsp lactis HN019 presents antimicrobial potential against periodontopathogens and modulates the immunological response of oral mucosa in periodontitis patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-10-14T21:19:36Z
dc.journal.volume
15
dc.journal.number
9
dc.journal.pagination
1-20; e0238425
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Invernici, Marcos M.. Universidade de Sao Paulo; Brasil
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Fil: Furlaneto, Flávia A. C.. Universidade de Sao Paulo; Brasil
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Fil: Salvador, Sérgio L. Universidade de Sao Paulo; Brasil
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Fil: Ouwehand, Arthur C.. Dupont, Nutrition and Health; Finlandia
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Fil: Salminen, Seppo. University of Turku. Functional Foods Forum; Finlandia
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Fil: Mantziari, Anastasia. University of Turku. Functional Foods Forum; Finlandia
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Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
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Fil: Ervolino, Edilson. São Paulo State University. Division of Histology, Department of Basic Sciences, Dental School of Araçatuba; Brasil
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Fil: Santana, Sandro Isaías. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Silva, Pedro Henrique Felix. Universidade de Sao Paulo; Brasil
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Fil: Messora, Michel R.. Universidade de Sao Paulo; Brasil
dc.journal.title
Plos One
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1371/journal.pone.0238425
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238425
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