Artículo
Differential Immune Response of Lactobacillus plantarum 286 Against Salmonella Typhimurium Infection in Conventional and Germ-Free Mice
Santos, Tizá Teles; Ornellas, Roberta Maria Dos Santos; Acurcio, Leonardo Borges; Sandes, Sávio Henrique Cicco; da Costa, Andréa Miura; Uetanabaro, Ana Paula Trovatti; Nicoli, Jacques Robert; Vinderola, Celso Gabriel
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Fecha de publicación:
10/2020
Editorial:
Springer Verlag Berlín
Revista:
Advances in Experimental Medicine and Biology
ISSN:
0065-2598
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We aimed at evaluating in vivo the probiotic potential of Lactobacillus plantarum 286 against Salmonella enterica serov. Typhimurium. Colonization capacity and antagonistic activity were determined in feces of gnotobiotic mice. Survival to infection, translocation, histopathology, IgA and cytokine levels (IL-10, IL-6, IFN-γ, TNF-α, TGF-β) were determined both in conventional and germ-free mice followed L. plantarum 286 administration and Salmonella infection. L. plantarum 286 colonized the intestine of gnotobiotic mice, where it produced antagonistic substances against S. Typhimurium. In conventional animals, the administration of this strain increased intestinal IgA levels and reduced the inflammatory response and the tissue damage caused by S. Typhimurium. Reduction of tissue damage in the intestine and liver of germ-free animals was also observed, however the immune response elicited was different in either model. L. plantarum 286 showed in vivo probiotic properties in both murine models. Probiotic capacity results may depend on the animal model chosen.
Palabras clave:
LPLANTARUM
,
GERM FREE
,
PROBIOTIC
,
MICE
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Licencia
Identificadores
Colecciones
Articulos(INLAIN)
Articulos de INST.DE LACTOLOGIA INDUSTRIAL
Articulos de INST.DE LACTOLOGIA INDUSTRIAL
Citación
Santos, Tizá Teles; Ornellas, Roberta Maria Dos Santos; Acurcio, Leonardo Borges; Sandes, Sávio Henrique Cicco; da Costa, Andréa Miura; et al.; Differential Immune Response of Lactobacillus plantarum 286 Against Salmonella Typhimurium Infection in Conventional and Germ-Free Mice; Springer Verlag Berlín; Advances in Experimental Medicine and Biology; 10-2020; 1-17
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