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dc.contributor.author
Paciullo, Francesco
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Bury, Loredana
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Noris, Patrizia
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Falcinelli, Emanuela
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Melazzini, Federica
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Orsini, Sara
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Zaninetti, Carlo
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Abdul Kadir, Rezan
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Obeng Tuudah, Deborah
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Heller, Paula Graciela
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Glembotsky, Ana Claudia
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Fabris, Fabrizio
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Rivera, Jose
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Lozano, Maria Luisa
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Butta, Nora
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Favier, Remi
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Cid, Ana Rosa
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Fouassier, Marc
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Podda, Gian Marco
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Santoro, Cristina
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Grandone, Elvira
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Henskens, Yvonne
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Nurden, Paquita
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Zieger, Barbara
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Cuker, Adam
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Devreese, Katrien
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Tosetto, Alberto
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De Candia, Erica
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Dupuis, Arnaud
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Miyazaki, Koji
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Othman, Maha
dc.contributor.author
Gresele, Paolo
dc.date.available
2020-10-28T12:27:22Z
dc.date.issued
2019-09
dc.identifier.citation
Paciullo, Francesco; Bury, Loredana; Noris, Patrizia; Falcinelli, Emanuela; Melazzini, Federica; et al.; Antithrombotic prophylaxis for surgery-associated venous thromboembolism risk in patients with inherited platelet disorders. The SPATA-DVT Study; Ferrata Storti Foundation; Haematologica; 105; 9-2019; 1948-1956
dc.identifier.issn
0390-6078
dc.identifier.uri
http://hdl.handle.net/11336/117012
dc.description.abstract
Major surgery is associated with an increased risk of venous thromboembolism, thus the application of mechanical or pharmacologic prophylaxis is recommended. The incidence of venous thromboembolism in patients with inherited platelet disorders undergoing surgical procedures is unknown and no information on the current use and safety of thromboprophylaxis, particularly of low-molecular-weight-heparin in these patients is available. Here we explored the approach to thromboprophylaxis and thrombotic outcomes in inherited platelet disorders patients undergoing surgery at venous thromboembolism-risk participating in the multicenter SPATA study. We evaluated 210 surgical procedures carried out in 155 patients with well-defined forms of inherited platelet disorders (venous thromboembolism-risk: 31% high, 28.6% intermediate, 25.2% low, 15.2% very low). The use of thromboprophylaxis was low (23.3% of procedures), with higher prevalence in orthopedic and gynecological surgeries, and was related to venous thromboembolism-risk. The most frequently employed thromboprophylaxis was mechanical and appeared to be effective, as no patients developed thrombosis, including patients belonging to the highest venous thromboembolism-risk classes. Low-molecular-weight-heparin use was low (10.5%) and it did not influence the incidence of post-surgical bleeding or of antihemorrhagic prohemostatic interventions. Two thromboembolic events were registered, both occurring after high venous thromboembolism-risk procedures in patients who did not receive thromboprophylaxis (4.7%). Our findings suggest that venous thromboembolism incidence is low in patients with inherited platelet disorders undergoing surgery at venous thromboembolism-risk and that it is predicted by the Caprini score. Mechanical thromboprophylaxis may be of benefit in patients with inherited platelet disorders undergoing invasive procedures at venous thromboembolism-risk and low-molecular-weight-heparin should be considered for major surgery.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Ferrata Storti Foundation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTITHROMBOTIC THERAPY
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DISORDERS OF PLATELET FUNCTION
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PLATELETS
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VENOUS THROMBOSIS
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Hematología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Antithrombotic prophylaxis for surgery-associated venous thromboembolism risk in patients with inherited platelet disorders. The SPATA-DVT Study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-05T16:03:22Z
dc.identifier.eissn
1592-8721
dc.journal.volume
105
dc.journal.pagination
1948-1956
dc.journal.pais
Italia
dc.journal.ciudad
Pavia, Italia
dc.description.fil
Fil: Paciullo, Francesco. Università di Perugia; Italia
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Fil: Bury, Loredana. Università di Perugia; Italia
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Fil: Noris, Patrizia. Universita Degli Studi Di Pavia; Italia
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Fil: Falcinelli, Emanuela. Università di Perugia; Italia
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Fil: Melazzini, Federica. Universita Degli Studi Di Pavia.; Italia
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Fil: Orsini, Sara. Università di Perugia; Italia
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Fil: Zaninetti, Carlo. Universita Degli Studi Di Pavia.; Italia
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Fil: Abdul Kadir, Rezan. Haemophilia Centre And Haemostasis Unit, Royal Free Fou; Reino Unido
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Fil: Obeng Tuudah, Deborah. Haemophilia Centre And Haemostasis Unit, Royal Free Fou; Reino Unido
dc.description.fil
Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Glembotsky, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
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Fil: Fabris, Fabrizio. Università di Padova; Italia
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Fil: Rivera, Jose. Universidad de Murcia; España
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Fil: Lozano, Maria Luisa. Universidad de Murcia; España
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Fil: Butta, Nora. Hospital Universitario la Paz; España
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Fil: Favier, Remi. French Reference Centre For Inherited Platelet Disorder; Francia
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Fil: Cid, Ana Rosa. Hospital Universitario y Politecnico la Fe; España
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Fil: Fouassier, Marc. French Reference Centre For Inherited Platelet Disorder; Francia
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Fil: Podda, Gian Marco. Università degli Studi di Milano; Italia
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Fil: Santoro, Cristina. Università degli studi di Roma "La Sapienza"; Italia
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Fil: Grandone, Elvira. Casa Sollievo Della Sofferenza,s.giovanni Rotondo; Italia
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Fil: Henskens, Yvonne. Maastricht University Medical Centre; Países Bajos
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Fil: Nurden, Paquita. French Reference Centre For Inherited Platelet Disorder; Francia
dc.description.fil
Fil: Zieger, Barbara. Albert Ludwigs University of Freiburg; Alemania
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Fil: Cuker, Adam. University of Pennsylvania; Estados Unidos
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Fil: Devreese, Katrien. University of Ghent; Bélgica
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Fil: Tosetto, Alberto. Hospital San Bortolo; Italia
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Fil: De Candia, Erica. Istituto Nazionale di Ricovero e Cura a Carattere Scientifico "Saverio de Bellis"; Italia
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Fil: Dupuis, Arnaud. French Reference Centre For Inherited Platelet Disorder; Francia
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Fil: Miyazaki, Koji. Kitasato University School Of Medicine; Japón
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Fil: Othman, Maha. Queens University; Canadá
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Fil: Gresele, Paolo. Università di Perugia; Italia
dc.journal.title
Haematologica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.haematologica.org/content/105/7/1948
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3324/haematol.2019.227876
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