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dc.contributor.author
Rios, Lizette E.  
dc.contributor.author
Vázquez Chagoyán, Juan Carlos  
dc.contributor.author
Pacheco, Antonio Ortega  
dc.contributor.author
Zago, María Paola  
dc.contributor.author
Garg, Nisha J.  
dc.date.available
2020-10-27T20:56:07Z  
dc.date.issued
2019-12  
dc.identifier.citation
Rios, Lizette E.; Vázquez Chagoyán, Juan Carlos; Pacheco, Antonio Ortega; Zago, María Paola; Garg, Nisha J.; Immunity and vaccine development efforts against Trypanosoma cruzi; Elsevier Science; Acta Tropica; 200; 105168; 12-2019; 1-11  
dc.identifier.issn
0001-706X  
dc.identifier.uri
http://hdl.handle.net/11336/116983  
dc.description.abstract
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ADJUVANTS  
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CHAGAS  
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IMMUNITY  
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PROPHYLACTIC  
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THERAPEUTIC  
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VACCINE  
dc.subject.classification
Parasitología  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Immunity and vaccine development efforts against Trypanosoma cruzi  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-05-19T19:45:07Z  
dc.journal.volume
200  
dc.journal.number
105168  
dc.journal.pagination
1-11  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Rios, Lizette E.. University of Texas Medical Branch; Estados Unidos  
dc.description.fil
Fil: Vázquez Chagoyán, Juan Carlos. Universidad Autónoma del Estado de México; México  
dc.description.fil
Fil: Pacheco, Antonio Ortega. Universidad Autónoma de Yucatán; México  
dc.description.fil
Fil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina  
dc.description.fil
Fil: Garg, Nisha J.. University of Texas Medical Branch; Estados Unidos  
dc.journal.title
Acta Tropica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.actatropica.2019.105168  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0001706X19303572  

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