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Artículo

A previous history of repeated amphetamine exposure modifies brain angiotensin II AT1 receptor functionality

Casarsa, Brenda SolangeIcon ; Marinzalda, María de Los AngelesIcon ; Marchese, Natalia AndreaIcon ; Paz, Maria ConstanzaIcon ; Vivas, Laura MartaIcon ; Bregonzio, C.; Baiardi, Gustavo CarlosIcon
Fecha de publicación: 10/2015
Editorial: Elsevier
Revista: Neuroscience
ISSN: 0306-4522
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Previous results from our laboratory showed that angiotensin II AT1 receptors (AT1-R) are involved in the neuroadaptative changes induced by amphetamine. The aim of the present work was to study functional and neurochemical responses to angiotensin II (ANG II) mediated by AT1-R activation in animals previously exposed to amphetamine. For this purpose male Wistar rats (250–320 g) were treated with amphetamine (2.5 mg/kg/day intraperitoneal) or saline for 5 days and implanted with intracerebroventricular (i.c.v.) cannulae. Seven days after the last amphetamine administration the animals received ANG II (400 pmol) i.c.v. One group was tested in a free choice paradigm for sodium (2% NaCl) and water intake and sacrificed for Fos immunoreactivity (Fos-IR) determinations. In a second group of rats, urine and plasma samples were collected for electrolytes and plasma renin activity determination and then they were sacrificed for Fos-IR determination in Oxytocinergic neurons (Fos-OT-IR). Results: Repeated amphetamine exposure (a) prevented the increase in sodium intake and Fos-IR cells in caudate-putamen and accumbens nucleus induced by ANG II i.c.v. (b) potentiated urinary sodium excretion and Fos-OT-IR in hypothalamus and (c) increased the inhibitory response in plasma renin activity, in response to ANG II i.c.v. Our results indicate a possible functional desensitisation of AT1-R in response to ANG II, induced by repeated amphetamine exposure. This functional AT1-R desensitisation allows to unmask the effects of ANG II i.c.v. mediated by oxytocin. We conclude that the long lasting changes in brain AT1-R functionality should be considered among the psychostimulant-induced neuroadaptations.
Palabras clave: At1 Receptors , Angiotensin Ii , Amphetamine , Sodiun Intake , Natriuresis , Oxytocin
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/11634
URL: http://www.sciencedirect.com/science/article/pii/S0306452215007599
DOI: http://dx.doi.org/10.1016/j.neuroscience.2015.08.027
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Articulos(IIBYT)
Articulos de INSTITUTO DE INVESTIGACIONES BIOLOGICAS Y TECNOLOGICAS
Citación
Casarsa, Brenda Solange; Marinzalda, María de Los Angeles; Marchese, Natalia Andrea; Paz, Maria Constanza; Vivas, Laura Marta; et al.; A previous history of repeated amphetamine exposure modifies brain angiotensin II AT1 receptor functionality; Elsevier; Neuroscience; 307; 10-2015; 1-13
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