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dc.contributor.author
Sváb, Domonkos
dc.contributor.author
Galli, Lucía
dc.contributor.author
Horváth, Balázs
dc.contributor.author
Maróti, Gergely
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Dobrindt, Ulrich
dc.contributor.author
Torres, Alfredo G.
dc.contributor.author
Rivas, Marta
dc.contributor.author
Tóth, István
dc.date.available
2017-01-18T20:57:49Z
dc.date.issued
2013-04
dc.identifier.citation
Sváb, Domonkos; Galli, Lucía; Horváth, Balázs; Maróti, Gergely; Dobrindt, Ulrich; et al.; The long polar fimbriae (lpf) operon and its flanking regions in atypical bovine Escherichia coli O157:H43 and STEC O136:H12 strains; Oxford University Press; Pathogens and Disease; 68; 1; 4-2013; 1-7
dc.identifier.issn
2049-632X
dc.identifier.uri
http://hdl.handle.net/11336/11603
dc.description.abstract
Long polar fimbriae (Lpf) are intestinal adhesins and important virulence factors of pathogenic Escherichia coli strains. We cloned and sequenced the lpf2-1 operon (lpf2ABCD) and its flanking regions of an intimin- and Shiga toxin-negative E. coli O157:H43 strain of bovine origin, and also sequenced the lpf2-1 operon of 6 additional atypical O157 bovine Escherichia coli strains of various serotypes. Nucleotide sequence comparison of these lpf operons showed sequence conservation as they contained only four polymorphic nucleotide positions. Investigation of these O157 strains as well as 13 Escherichia coli Reference Collection (ECOR) strains carrying the lpf2-1 allele revealed high degree of sequence conservation in the lpf2 flanking regions. The lpf2-1 allele is also present in a bovine Shiga toxin-producing E. coli STEC O136:H12 strain and in vitro adherence assays revealed that the absence of lpf2-1 in this strain did not affect its host cell-binding properties. Our data indicate that lpf2 loci is highly conserved in E. coli isolates, however, its role in adherence might be masked by other uncharacterized adhesins.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Escherichia Coli
dc.subject
O157:H43
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Atypical E. Coli
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Lpf
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O136:H12
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The long polar fimbriae (lpf) operon and its flanking regions in atypical bovine Escherichia coli O157:H43 and STEC O136:H12 strains
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-17T19:01:51Z
dc.journal.volume
68
dc.journal.number
1
dc.journal.pagination
1-7
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Sváb, Domonkos. Hungarian Academy of Sciences; Hungría
dc.description.fil
Fil: Galli, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud; Argentina
dc.description.fil
Fil: Horváth, Balázs. Hungarian Academy of Sciences; Hungría. Bay Zoltán Nonprofit Research; Hungría
dc.description.fil
Fil: Maróti, Gergely. Hungarian Academy of Sciences; Hungría. Bay Zoltán Nonprofit Research; Hungría
dc.description.fil
Fil: Dobrindt, Ulrich. University of Münster; Alemania
dc.description.fil
Fil: Torres, Alfredo G.. University Of Texas; Estados Unidos
dc.description.fil
Fil: Rivas, Marta. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud; Argentina
dc.description.fil
Fil: Tóth, István . Hungarian Academy of Sciences; Hungría
dc.journal.title
Pathogens and Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/2049-632X.12038
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://femspd.oxfordjournals.org/content/68/1/1
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821771/
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