Mostrar el registro sencillo del ítem
dc.contributor.author
Paladino, Natalia
dc.contributor.author
Flores, Ana Claudia
dc.contributor.author
Marcos, Cintia Yanina
dc.contributor.author
Fainboim, Hugo
dc.contributor.author
Theiler, Gerardo Raul
dc.contributor.author
Arruvito, Maria Lourdes
dc.contributor.author
Williams, F.
dc.contributor.author
Middleton, D.
dc.contributor.author
Fainboim, Leonardo
dc.date.available
2020-10-15T14:42:20Z
dc.date.issued
2007-12
dc.identifier.citation
Paladino, Natalia; Flores, Ana Claudia; Marcos, Cintia Yanina; Fainboim, Hugo; Theiler, Gerardo Raul; et al.; Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 109-111
dc.identifier.issn
0001-2815
dc.identifier.uri
http://hdl.handle.net/11336/115967
dc.description.abstract
This study was designed to investigate the role of KIR genes in the outcome of HCV infection. In patients who cleared the virus (HCV RNA-) we found a decrease of 2DL2 (p=0.04), and 2DS2 (p=0.014) accompanied by an increase of 2DS5 (p=0.04). Those RNA+ patients with elevated levels of hepatic transaminases (HCV RNA+ elevatedALT) showed an increased frequency of 2DS3 (p=0.018). Additionally, in cirrhotic patients we found an increased frequency of individuals having two copies of 3DS1 and HLA-Bw4 (p=0.016). We conclude that higher NK cytotoxicity might be associated with a worse progression of the HCV infection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
natural killer cells
dc.subject
HLA
dc.subject
cirrhosis
dc.subject
hepatitis C virus
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Increased frequencies of activating natural killer receptors are associated with liver injury in individuals who do not eliminate hepatitis C virus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-10-14T21:24:59Z
dc.journal.volume
69
dc.journal.number
SUPPL. 1
dc.journal.pagination
109-111
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Flores, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Marcos, Cintia Yanina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
dc.description.fil
Fil: Theiler, Gerardo Raul. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Arruvito, Maria Lourdes. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Williams, F.. Belfast City Hospital; Irlanda
dc.description.fil
Fil: Middleton, D.. Belfast City Hospital; Irlanda
dc.description.fil
Fil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
dc.journal.title
Tissue Antigens
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0039.2006.762_7.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1399-0039.2006.762_7.x
Archivos asociados
Tamaño:
100.3Kb
Formato:
PDF