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dc.contributor.author
Ferder, Leon Fernando
dc.contributor.author
Martín Giménez, Virna Margarita
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Inserra, Felipe
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Tajer, Carlos Daniel
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Antonietti, Laura
dc.contributor.author
Mariani, Javier
dc.contributor.author
Manucha, Walter Ariel Fernando
dc.date.available
2020-10-13T17:35:47Z
dc.date.issued
2020-07
dc.identifier.citation
Ferder, Leon Fernando; Martín Giménez, Virna Margarita; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; et al.; Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic; American Physiological Society; American Journal Of Physiology-lung Cellular And Molecular Physiology; 319; 6; 7-2020; L941-L948
dc.identifier.issn
1040-0605
dc.identifier.uri
http://hdl.handle.net/11336/115804
dc.description.abstract
COVID-19 pandemic reached most of the countries of the world causing death as a result of the inflammatory storm, oxidative imbalance from the severe acute respiratory syndrome. Many laboratories fight against the clock in search of a specific and definitive treatment. Additionally, it is interesting the evaluation -preventive and therapeutic- of the existing pharmacological agents that could be used to avoid or attenuate the severity at the pulmonary level as well as in other organs of the body is of interest. In this regard, there is evidence of vitamin D that -in high doses- could be a promising preventive and therapeutic option, especially if it is considered that this hormone modulates the same inflammatory and oxidative signaling pathways triggered during COVID-19 infection. Similarly, it is useful to highlight that vitamin D is opposed to the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response by COVID-19. Finally, the purpose of this review is to call for reflection and to discuss the suggestion to implement vitamin D for preventive/therapeutic purposes in groups at risk or infected with COVID-19. This proposal could be extended to the entire community as a preventive measure. Also, our objective points to the debate and critical reflection of health professionals and health policymakers in a way that contributes to the development of consistent clinical designs to evaluate the possible benefits of using high doses of vitamin D for the benefit of public health in pandemic time.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physiological Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COVID-19
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VITAMIN D
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RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
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PREVENTION/TREATMENT
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-10-13T15:57:51Z
dc.journal.volume
319
dc.journal.number
6
dc.journal.pagination
L941-L948
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
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Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Inserra, Felipe. Universidad Maimónides; Argentina
dc.description.fil
Fil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
dc.description.fil
Fil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; Argentina
dc.description.fil
Fil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
dc.description.fil
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
dc.journal.title
American Journal Of Physiology-lung Cellular And Molecular Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/abs/10.1152/ajplung.00186.2020
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajplung.00186.2020
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