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dc.contributor.author
Valdez, Diego Javier
dc.contributor.author
Nieto, Paula Sofia
dc.contributor.author
Della Costa, Natalia Soledad
dc.contributor.author
Schurrer, Clemar
dc.contributor.author
Guido, Mario Eduardo
dc.date.available
2017-01-18T19:04:16Z
dc.date.issued
2015-01
dc.identifier.citation
Valdez, Diego Javier; Nieto, Paula Sofia; Della Costa, Natalia Soledad; Schurrer, Clemar; Guido, Mario Eduardo; Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 56; 2; 1-2015; 730-737
dc.identifier.issn
0146-0404
dc.identifier.uri
http://hdl.handle.net/11336/11570
dc.description.abstract
PURPOSE. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions. METHODS. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions. RESULTS. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day. CONCLUSIONS. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of lig
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Association For Research In Vision And Ophthalmology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pupillari Light Reflexes
dc.subject
Melanopsin
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Blindness
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Circadian Rhythm
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-11-03T19:16:43Z
dc.journal.volume
56
dc.journal.number
2
dc.journal.pagination
730-737
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Rockville
dc.description.fil
Fil: Valdez, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
dc.description.fil
Fil: Nieto, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
dc.description.fil
Fil: Della Costa, Natalia Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentina. Universidad Nacional de Córdoba; Argentina
dc.description.fil
Fil: Schurrer, Clemar. Universidad Tecnologica Nacional. Facultad Regional Cordoba; Argentina
dc.description.fil
Fil: Guido, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
dc.journal.title
Investigative Ophthalmology & Visual Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://iovs.arvojournals.org/article.aspx?articleid=2212827
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1167/iovs.14-15481


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