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dc.contributor.author Valdez, Diego Javier
dc.contributor.author Nieto, Paula Sofia
dc.contributor.author Della Costa, Natalia Soledad
dc.contributor.author Schurrer, Clemar
dc.contributor.author Guido, Mario Eduardo
dc.date.available 2017-01-18T19:04:16Z
dc.date.issued 2015-01
dc.identifier.citation Valdez, Diego Javier; Nieto, Paula Sofia; Della Costa, Natalia Soledad; Schurrer, Clemar; Guido, Mario Eduardo; Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 56; 2; 1-2015; 730-737
dc.identifier.issn 0146-0404
dc.identifier.uri http://hdl.handle.net/11336/11570
dc.description.abstract PURPOSE. The vertebrate inner retina has a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the nonvisual photopigment melanopsin. The intrinsically photosensitive retinal ganglion cells send light information from the environment to the brain to control, among other parameters, the amount of energy entering the eyes through the pupillary light reflex (PLR). A daily variation in the PLR in both mice and humans has recently been shown, indicating circadian control of this response. In a previous work involving the sensitivity spectra for the PLR, we showed that blind chickens (GUCY1*) display the highest sensitivity to light of 480 nm. The aim of the present study was to evaluate the potential circadian control of PLRs in blind birds under scotopic conditions. METHODS. Circadian PLR was performed on GUCY1* chickens with lights of different wavelengths (white or blue light of 475 nm) under scotopic conditions. RESULTS. We found a significant daily variation in the PLRs of chickens exposed to white or blue light of 475 nm, with increased sensitivity at circadian time 6 during the subjective day. CONCLUSIONS. Our observations clearly point to circadian control of PLRs even in blindness, strongly indicating that both the entry of lig
dc.format application/pdf
dc.language.iso eng
dc.publisher Association For Research In Vision And Ophthalmology
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject PUPILLARI LIGHT REFLEXES
dc.subject MELANOPSIN
dc.subject BLINDNESS
dc.subject CIRCADIAN RHYTHM
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Circadian Control of the Pupillary Light Responses in an Avian Model of Blindness, the GUCY1* Chickens
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-11-03T19:16:43Z
dc.journal.volume 56
dc.journal.number 2
dc.journal.pagination 730-737
dc.journal.pais Estados Unidos
dc.journal.ciudad Rockville
dc.description.fil Fil: Valdez, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
dc.description.fil Fil: Nieto, Paula Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
dc.description.fil Fil: Della Costa, Natalia Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentina. Universidad Nacional de Córdoba; Argentina
dc.description.fil Fil: Schurrer, Clemar. Universidad Tecnologica Nacional. Facultad Regional Cordoba; Argentina
dc.description.fil Fil: Guido, Mario Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina
dc.journal.title Investigative Ophthalmology & Visual Science
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://iovs.arvojournals.org/article.aspx?articleid=2212827
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1167/iovs.14-15481


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)