Mostrar el registro sencillo del ítem
dc.contributor.author
Ramos Elizagaray, Sabrina I.
dc.contributor.author
Soria, Elio Andres
dc.date.available
2017-01-17T21:55:38Z
dc.date.issued
2014-07
dc.identifier.citation
Ramos Elizagaray, Sabrina I.; Soria, Elio Andres; Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches; Bentham Science Publishers; Recent Patents on Inflammation and Allergy Drug Discovery; 8; 2; 7-2014; 92-103
dc.identifier.issn
1872-213X
dc.identifier.uri
http://hdl.handle.net/11336/11539
dc.description.abstract
Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Antioxidant
dc.subject
Arsenicosis
dc.subject
Chemoprevention
dc.subject
Phytomedicine
dc.subject
Immunomodulation
dc.subject
Polyphenol
dc.subject.classification
Farmacología y Farmacia
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-01-13T19:40:11Z
dc.identifier.eissn
2212-2710
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
92-103
dc.journal.pais
Emiratos Árabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Ramos Elizagaray, Sabrina I.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina. Consejo Interuniversitario Nacional; Argentina
dc.description.fil
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina
dc.journal.title
Recent Patents on Inflammation and Allergy Drug Discovery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/recent-patents-on-inflammation-and-allergy-drug-discovery/volume/8/issue/2/page/92/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.2174/1872213X08666140619104944
Archivos asociados