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dc.contributor.author
Hoch, Nicolas Carlos  
dc.contributor.author
Polo Ilacqua, Luis Mariano  
dc.date.available
2020-09-29T18:01:31Z  
dc.date.issued
2020-01  
dc.identifier.citation
Hoch, Nicolas Carlos; Polo Ilacqua, Luis Mariano; ADP-ribosylation: From molecular mechanisms to human disease; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 1-2020; 1-14  
dc.identifier.issn
1415-4757  
dc.identifier.uri
http://hdl.handle.net/11336/115088  
dc.description.abstract
Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Sociedade Brasileira de Genética  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ADP RIBOSE  
dc.subject
DNA DAMAGE RESPONSE  
dc.subject
DNA REPAIR  
dc.subject
PARP  
dc.subject
PARTHANATOS  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
ADP-ribosylation: From molecular mechanisms to human disease  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-06-30T14:17:37Z  
dc.identifier.eissn
1678-4685  
dc.journal.volume
43  
dc.journal.number
1  
dc.journal.pagination
1-14  
dc.journal.pais
Brasil  
dc.journal.ciudad
Sao Paulo  
dc.description.fil
Fil: Hoch, Nicolas Carlos. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Polo Ilacqua, Luis Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. University of Sussex; Reino Unido  
dc.journal.title
Genetics and Molecular Biology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304&lng=en&nrm=iso  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1590/1678-4685-gmb-2019-0075  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198025/  

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