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Artículo

Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat

Baiardi, Gustavo CarlosIcon ; Macova, Miroslava; Armando, Ines; Ando, Hiromichi; Tyurmin, Dmitri; Saavedra, Juan M.
Fecha de publicación: 22/09/2004
Editorial: Elsevier Science
Revista: Regulatory Peptides
ISSN: 0167-0115
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Médicas

Resumen

We studied renal AT1 and AT2 receptors in male, female, ovariectomized and ovariectomized-estrogen-treated Wistar-Hanover and Wistar-Kyoto rats. AT1 receptors and AT1A receptor mRNA predominated, with no significant differences between males and females. AT 2 receptor expression was restricted in female rats to the capsule, the transition zone between outer and inner medulla, the endothelium lining the papilla, and arcuate arteries and veins. There were no AT2 receptors in male rats, while male mice express substantial numbers of estrogen-dependent AT2 receptors. Arcuate arteries and veins expressed AT1B mRNA in males and females, and AT2 mRNA in females only. AT 1 receptor and AT2 receptor expression were estrogen-dependent, with increases in AT1 and AT2 receptor expression after estrogen treatment in ovariectomized rats. Estrogen treatment increased prostaglandin E2 (PGE2) and cGMP concentrations in the renal medulla, and eNOS expression in cortical arteries. In rodents, expression of renal Angiotensin II receptor types is estrogen-dependent, with significant species, strain and area differences. Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney. © 2004 Published by Elsevier B.V.
Palabras clave: KIDNEY FUNCTION , OVARIAN HORMONES , PROSTAGLANDINS , RENIN-ANGIOTENSIN SYSTEM
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/114982
DOI: http://dx.doi.org/10.1016/j.regpep.2004.06.021
URL: https://www.sciencedirect.com/science/article/abs/pii/S0167011504002113
Colecciones
Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Baiardi, Gustavo Carlos; Macova, Miroslava; Armando, Ines; Ando, Hiromichi; Tyurmin, Dmitri; et al.; Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat; Elsevier Science; Regulatory Peptides; 124; 1-3; 22-9-2004; 7-17
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